Stem cells as potential therapeutics for hearing loss

Hearing impairment is a global health problem. Stem cell therapy has become a cutting-edge approach to tissue regeneration. In this review, the recent advances in stem cell therapy for hearing loss have been discussed. Nanomaterials can modulate the stem cell microenvironment to augment the therapeu...

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Autores principales: Fang, Qiaojun, Wei, Yongjie, Zhang, Yuhua, Cao, Wei, Yan, Lin, Kong, Mengdie, Zhu, Yongjun, Xu, Yan, Guo, Lingna, Zhang, Lei, Wang, Weiqing, Yu, Yafeng, Sun, Jingwu, Yang, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512725/
https://www.ncbi.nlm.nih.gov/pubmed/37746148
http://dx.doi.org/10.3389/fnins.2023.1259889
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author Fang, Qiaojun
Wei, Yongjie
Zhang, Yuhua
Cao, Wei
Yan, Lin
Kong, Mengdie
Zhu, Yongjun
Xu, Yan
Guo, Lingna
Zhang, Lei
Wang, Weiqing
Yu, Yafeng
Sun, Jingwu
Yang, Jianming
author_facet Fang, Qiaojun
Wei, Yongjie
Zhang, Yuhua
Cao, Wei
Yan, Lin
Kong, Mengdie
Zhu, Yongjun
Xu, Yan
Guo, Lingna
Zhang, Lei
Wang, Weiqing
Yu, Yafeng
Sun, Jingwu
Yang, Jianming
author_sort Fang, Qiaojun
collection PubMed
description Hearing impairment is a global health problem. Stem cell therapy has become a cutting-edge approach to tissue regeneration. In this review, the recent advances in stem cell therapy for hearing loss have been discussed. Nanomaterials can modulate the stem cell microenvironment to augment the therapeutic effects further. The potential of combining nanomaterials with stem cells for repairing and regenerating damaged inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) has also been discussed. Stem cell-derived exosomes can contribute to the repair and regeneration of damaged tissue, and the research progress on exosome-based hearing loss treatment has been summarized as well. Despite stem cell therapy’s technical and practical limitations, the findings reported so far are promising and warrant further investigation for eventual clinical translation.
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spelling pubmed-105127252023-09-22 Stem cells as potential therapeutics for hearing loss Fang, Qiaojun Wei, Yongjie Zhang, Yuhua Cao, Wei Yan, Lin Kong, Mengdie Zhu, Yongjun Xu, Yan Guo, Lingna Zhang, Lei Wang, Weiqing Yu, Yafeng Sun, Jingwu Yang, Jianming Front Neurosci Neuroscience Hearing impairment is a global health problem. Stem cell therapy has become a cutting-edge approach to tissue regeneration. In this review, the recent advances in stem cell therapy for hearing loss have been discussed. Nanomaterials can modulate the stem cell microenvironment to augment the therapeutic effects further. The potential of combining nanomaterials with stem cells for repairing and regenerating damaged inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) has also been discussed. Stem cell-derived exosomes can contribute to the repair and regeneration of damaged tissue, and the research progress on exosome-based hearing loss treatment has been summarized as well. Despite stem cell therapy’s technical and practical limitations, the findings reported so far are promising and warrant further investigation for eventual clinical translation. Frontiers Media S.A. 2023-09-07 /pmc/articles/PMC10512725/ /pubmed/37746148 http://dx.doi.org/10.3389/fnins.2023.1259889 Text en Copyright © 2023 Fang, Wei, Zhang, Cao, Yan, Kong, Zhu, Xu, Guo, Zhang, Wang, Yu, Sun and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Fang, Qiaojun
Wei, Yongjie
Zhang, Yuhua
Cao, Wei
Yan, Lin
Kong, Mengdie
Zhu, Yongjun
Xu, Yan
Guo, Lingna
Zhang, Lei
Wang, Weiqing
Yu, Yafeng
Sun, Jingwu
Yang, Jianming
Stem cells as potential therapeutics for hearing loss
title Stem cells as potential therapeutics for hearing loss
title_full Stem cells as potential therapeutics for hearing loss
title_fullStr Stem cells as potential therapeutics for hearing loss
title_full_unstemmed Stem cells as potential therapeutics for hearing loss
title_short Stem cells as potential therapeutics for hearing loss
title_sort stem cells as potential therapeutics for hearing loss
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512725/
https://www.ncbi.nlm.nih.gov/pubmed/37746148
http://dx.doi.org/10.3389/fnins.2023.1259889
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