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The role of C-peptide in diabetes and its complications: an updated review

Worldwide, diabetes and its complications have seriously affected people’s quality of life and become a serious public health problem. C-peptide is not only an indicator of pancreatic β-cell function, but also a biologically active peptide that can bind to cell membrane surface signaling molecules a...

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Autores principales: Chen, Jintao, Huang, Yajing, Liu, Chuanfeng, Chi, Jingwei, Wang, Yangang, Xu, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512826/
https://www.ncbi.nlm.nih.gov/pubmed/37745697
http://dx.doi.org/10.3389/fendo.2023.1256093
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author Chen, Jintao
Huang, Yajing
Liu, Chuanfeng
Chi, Jingwei
Wang, Yangang
Xu, Lili
author_facet Chen, Jintao
Huang, Yajing
Liu, Chuanfeng
Chi, Jingwei
Wang, Yangang
Xu, Lili
author_sort Chen, Jintao
collection PubMed
description Worldwide, diabetes and its complications have seriously affected people’s quality of life and become a serious public health problem. C-peptide is not only an indicator of pancreatic β-cell function, but also a biologically active peptide that can bind to cell membrane surface signaling molecules and activate downstream signaling pathways to play antioxidant, anti-apoptotic and inflammatory roles, or regulate cellular transcription through internalization. It is complex how C-peptide is related to diabetic complications. Both deficiencies and overproduction can lead to complications, but their mechanisms of action may be different. C-peptide replacement therapy has shown beneficial effects on diabetic complications in animal models when C-peptide is deficient, but results from clinical trials have been unsatisfactory. The complex pattern of the relationship between C-peptide and diabetic chronic complications has not yet been fully understood. Future basic and clinical studies of C-peptide replacement therapies will need to focus on baseline levels of C-peptide in addition to more attention also needs to be paid to post-treatment C-peptide levels to explore the optimal range of fasting C-peptide and postprandial C-peptide maintenance.
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spelling pubmed-105128262023-09-22 The role of C-peptide in diabetes and its complications: an updated review Chen, Jintao Huang, Yajing Liu, Chuanfeng Chi, Jingwei Wang, Yangang Xu, Lili Front Endocrinol (Lausanne) Endocrinology Worldwide, diabetes and its complications have seriously affected people’s quality of life and become a serious public health problem. C-peptide is not only an indicator of pancreatic β-cell function, but also a biologically active peptide that can bind to cell membrane surface signaling molecules and activate downstream signaling pathways to play antioxidant, anti-apoptotic and inflammatory roles, or regulate cellular transcription through internalization. It is complex how C-peptide is related to diabetic complications. Both deficiencies and overproduction can lead to complications, but their mechanisms of action may be different. C-peptide replacement therapy has shown beneficial effects on diabetic complications in animal models when C-peptide is deficient, but results from clinical trials have been unsatisfactory. The complex pattern of the relationship between C-peptide and diabetic chronic complications has not yet been fully understood. Future basic and clinical studies of C-peptide replacement therapies will need to focus on baseline levels of C-peptide in addition to more attention also needs to be paid to post-treatment C-peptide levels to explore the optimal range of fasting C-peptide and postprandial C-peptide maintenance. Frontiers Media S.A. 2023-09-07 /pmc/articles/PMC10512826/ /pubmed/37745697 http://dx.doi.org/10.3389/fendo.2023.1256093 Text en Copyright © 2023 Chen, Huang, Liu, Chi, Wang and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Chen, Jintao
Huang, Yajing
Liu, Chuanfeng
Chi, Jingwei
Wang, Yangang
Xu, Lili
The role of C-peptide in diabetes and its complications: an updated review
title The role of C-peptide in diabetes and its complications: an updated review
title_full The role of C-peptide in diabetes and its complications: an updated review
title_fullStr The role of C-peptide in diabetes and its complications: an updated review
title_full_unstemmed The role of C-peptide in diabetes and its complications: an updated review
title_short The role of C-peptide in diabetes and its complications: an updated review
title_sort role of c-peptide in diabetes and its complications: an updated review
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512826/
https://www.ncbi.nlm.nih.gov/pubmed/37745697
http://dx.doi.org/10.3389/fendo.2023.1256093
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