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Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis

AIMS/INTRODUCTION: There has been conflicting evidence regarding the role of prediabetes as a risk factor of lung cancer. A systemic review and meta‐analysis was conducted to determine the relationship between prediabetes and lung cancer incidence and mortality in general adult populations. MATERIAL...

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Autores principales: Shen, Enjian, Chen, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512911/
https://www.ncbi.nlm.nih.gov/pubmed/37517054
http://dx.doi.org/10.1111/jdi.14057
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author Shen, Enjian
Chen, Xi
author_facet Shen, Enjian
Chen, Xi
author_sort Shen, Enjian
collection PubMed
description AIMS/INTRODUCTION: There has been conflicting evidence regarding the role of prediabetes as a risk factor of lung cancer. A systemic review and meta‐analysis was conducted to determine the relationship between prediabetes and lung cancer incidence and mortality in general adult populations. MATERIALS AND METHODS: Observational studies relevant to the objective were found in Medline, Embase, Cochrane Library, and Web of Science. By incorporating potential heterogeneity into the model, a randomized‐effects model was selected. RESULTS: Ten cohort studies were included. People with prediabetes were associated with a mildly increased risk of lung cancer incidence compared with controls with normoglycemia (risk ratio [RR]: 1.09, 95% confidence interval [CI]: 1.01–1.18, P = 0.03; I(2) = 79%), which was mainly observed in men rather than in women (RR: 1.07 vs 0.99, P for subgroup difference < 0.001). Prediabetes was related to a higher risk of lung cancer mortality (RR: 1.19, 95% CI: 1.02–1.39, P = 0.03; I(2) = 52%), and the results were consistent in both men and women (P for subgroup difference = 0.67). The association between prediabetes and lung cancer incidence or mortality did not appear to be significantly affected by different definitions of prediabetes (P for subgroup difference = 0.27 and 0.37). CONCLUSIONS: Prediabetes might be associated with a mildly increased risk of lung cancer incidence in men, but not in women. In addition, prediabetes may be related to a higher risk of lung cancer mortality in the adult population.
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spelling pubmed-105129112023-09-22 Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis Shen, Enjian Chen, Xi J Diabetes Investig Articles AIMS/INTRODUCTION: There has been conflicting evidence regarding the role of prediabetes as a risk factor of lung cancer. A systemic review and meta‐analysis was conducted to determine the relationship between prediabetes and lung cancer incidence and mortality in general adult populations. MATERIALS AND METHODS: Observational studies relevant to the objective were found in Medline, Embase, Cochrane Library, and Web of Science. By incorporating potential heterogeneity into the model, a randomized‐effects model was selected. RESULTS: Ten cohort studies were included. People with prediabetes were associated with a mildly increased risk of lung cancer incidence compared with controls with normoglycemia (risk ratio [RR]: 1.09, 95% confidence interval [CI]: 1.01–1.18, P = 0.03; I(2) = 79%), which was mainly observed in men rather than in women (RR: 1.07 vs 0.99, P for subgroup difference < 0.001). Prediabetes was related to a higher risk of lung cancer mortality (RR: 1.19, 95% CI: 1.02–1.39, P = 0.03; I(2) = 52%), and the results were consistent in both men and women (P for subgroup difference = 0.67). The association between prediabetes and lung cancer incidence or mortality did not appear to be significantly affected by different definitions of prediabetes (P for subgroup difference = 0.27 and 0.37). CONCLUSIONS: Prediabetes might be associated with a mildly increased risk of lung cancer incidence in men, but not in women. In addition, prediabetes may be related to a higher risk of lung cancer mortality in the adult population. John Wiley and Sons Inc. 2023-07-30 /pmc/articles/PMC10512911/ /pubmed/37517054 http://dx.doi.org/10.1111/jdi.14057 Text en © 2023 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Articles
Shen, Enjian
Chen, Xi
Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis
title Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis
title_full Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis
title_fullStr Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis
title_full_unstemmed Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis
title_short Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis
title_sort prediabetes and the risk of lung cancer incidence and mortality: a meta‐analysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512911/
https://www.ncbi.nlm.nih.gov/pubmed/37517054
http://dx.doi.org/10.1111/jdi.14057
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