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Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis
AIMS/INTRODUCTION: There has been conflicting evidence regarding the role of prediabetes as a risk factor of lung cancer. A systemic review and meta‐analysis was conducted to determine the relationship between prediabetes and lung cancer incidence and mortality in general adult populations. MATERIAL...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512911/ https://www.ncbi.nlm.nih.gov/pubmed/37517054 http://dx.doi.org/10.1111/jdi.14057 |
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author | Shen, Enjian Chen, Xi |
author_facet | Shen, Enjian Chen, Xi |
author_sort | Shen, Enjian |
collection | PubMed |
description | AIMS/INTRODUCTION: There has been conflicting evidence regarding the role of prediabetes as a risk factor of lung cancer. A systemic review and meta‐analysis was conducted to determine the relationship between prediabetes and lung cancer incidence and mortality in general adult populations. MATERIALS AND METHODS: Observational studies relevant to the objective were found in Medline, Embase, Cochrane Library, and Web of Science. By incorporating potential heterogeneity into the model, a randomized‐effects model was selected. RESULTS: Ten cohort studies were included. People with prediabetes were associated with a mildly increased risk of lung cancer incidence compared with controls with normoglycemia (risk ratio [RR]: 1.09, 95% confidence interval [CI]: 1.01–1.18, P = 0.03; I(2) = 79%), which was mainly observed in men rather than in women (RR: 1.07 vs 0.99, P for subgroup difference < 0.001). Prediabetes was related to a higher risk of lung cancer mortality (RR: 1.19, 95% CI: 1.02–1.39, P = 0.03; I(2) = 52%), and the results were consistent in both men and women (P for subgroup difference = 0.67). The association between prediabetes and lung cancer incidence or mortality did not appear to be significantly affected by different definitions of prediabetes (P for subgroup difference = 0.27 and 0.37). CONCLUSIONS: Prediabetes might be associated with a mildly increased risk of lung cancer incidence in men, but not in women. In addition, prediabetes may be related to a higher risk of lung cancer mortality in the adult population. |
format | Online Article Text |
id | pubmed-10512911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105129112023-09-22 Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis Shen, Enjian Chen, Xi J Diabetes Investig Articles AIMS/INTRODUCTION: There has been conflicting evidence regarding the role of prediabetes as a risk factor of lung cancer. A systemic review and meta‐analysis was conducted to determine the relationship between prediabetes and lung cancer incidence and mortality in general adult populations. MATERIALS AND METHODS: Observational studies relevant to the objective were found in Medline, Embase, Cochrane Library, and Web of Science. By incorporating potential heterogeneity into the model, a randomized‐effects model was selected. RESULTS: Ten cohort studies were included. People with prediabetes were associated with a mildly increased risk of lung cancer incidence compared with controls with normoglycemia (risk ratio [RR]: 1.09, 95% confidence interval [CI]: 1.01–1.18, P = 0.03; I(2) = 79%), which was mainly observed in men rather than in women (RR: 1.07 vs 0.99, P for subgroup difference < 0.001). Prediabetes was related to a higher risk of lung cancer mortality (RR: 1.19, 95% CI: 1.02–1.39, P = 0.03; I(2) = 52%), and the results were consistent in both men and women (P for subgroup difference = 0.67). The association between prediabetes and lung cancer incidence or mortality did not appear to be significantly affected by different definitions of prediabetes (P for subgroup difference = 0.27 and 0.37). CONCLUSIONS: Prediabetes might be associated with a mildly increased risk of lung cancer incidence in men, but not in women. In addition, prediabetes may be related to a higher risk of lung cancer mortality in the adult population. John Wiley and Sons Inc. 2023-07-30 /pmc/articles/PMC10512911/ /pubmed/37517054 http://dx.doi.org/10.1111/jdi.14057 Text en © 2023 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Articles Shen, Enjian Chen, Xi Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis |
title | Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis |
title_full | Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis |
title_fullStr | Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis |
title_full_unstemmed | Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis |
title_short | Prediabetes and the risk of lung cancer incidence and mortality: A meta‐analysis |
title_sort | prediabetes and the risk of lung cancer incidence and mortality: a meta‐analysis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512911/ https://www.ncbi.nlm.nih.gov/pubmed/37517054 http://dx.doi.org/10.1111/jdi.14057 |
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