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Impact of consuming a Mediterranean-style diet during pregnancy on neurodevelopmental disabilities in offspring: results from the Boston Birth Cohort

BACKGROUND: While consuming a Mediterranean-style diet (MSD) among pregnant women is expected to affect offspring neurodevelopment, the current evidence is limited. This prospective birth cohort study aimed to explore the association of maternal MSD with neurodevelopmental disabilities (NDD) in offs...

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Autores principales: Che, Xiaoyu, Gross, Susan M., Wang, Guoying, Hong, Xiumei, Pearson, Colleen, Bartell, Tami, Wang, Xiaobin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513021/
https://www.ncbi.nlm.nih.gov/pubmed/37744413
http://dx.doi.org/10.1097/PN9.0000000000000047
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author Che, Xiaoyu
Gross, Susan M.
Wang, Guoying
Hong, Xiumei
Pearson, Colleen
Bartell, Tami
Wang, Xiaobin
author_facet Che, Xiaoyu
Gross, Susan M.
Wang, Guoying
Hong, Xiumei
Pearson, Colleen
Bartell, Tami
Wang, Xiaobin
author_sort Che, Xiaoyu
collection PubMed
description BACKGROUND: While consuming a Mediterranean-style diet (MSD) among pregnant women is expected to affect offspring neurodevelopment, the current evidence is limited. This prospective birth cohort study aimed to explore the association of maternal MSD with neurodevelopmental disabilities (NDD) in offspring, especially among children born to mothers with overweight or obesity (OWO) and/or diabetes mellitus (DM) since they have a higher risk for oxidative stress and immune/metabolic disturbances. METHODS: We analyzed data from a subgroup of mother–child dyads enrolled in the Boston Birth Cohort. Maternal dietary information (via food frequency questionnaires, Food frequency questionnaires [FFQ]) and sociodemographic information were obtained via in-person interviews within 24 to 72 hours postpartum. Maternal clinical information and child diagnosis of NDD including autism, attention-deficit/hyperactivity disorder (ADHD), and other developmental disabilities (DD) were extracted from medical records. A Mediterranean-style diet score (MSDS) was calculated using the FFQ. The association of maternal MSDS with NDD, autism, ADHD, and other DD was evaluated using multivariable logistic regression models adjusted for pertinent covariates. RESULTS: This study included 3153 mother–child pairs, from which we identified diagnoses of 1362 (43.2%) NDD, including 123 (3.9%) case of autism, 445 (14.1%) ADHD, and 794 (25.2%) other DD. In the overall sample, women with a higher maternal MSDS (per standard deviation increase) were less likely to have offspring with NDD (adjusted odds ratio [OR]: 0.904, 95% confidence interval [CI]: 0.817–1.000; P value: 0.049). Using MSDS quintile 1 as the reference, being in the combined group of quintiles 3–5 was associated with a 26% lower likelihood of NDD (adjusted OR: 0.738, 95% CI: 0.572–0.951; P value: 0.019). When stratified by mothers with OWO/DM vs. without OWO/DM, the association between maternal MSDS and offspring NDD was greater in children born to mothers with OWO/DM. CONCLUSIONS: In this prospective birth cohort, a higher maternal MSDS was associated with a lower likelihood of NDD in the offspring. Furthermore, this association of maternal MSDS with offspring NDD was greater in children born to women with OWO/DM. More studies are needed to replicate the findings and further analyze NDD subgroups and explore underlying molecular pathways.
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spelling pubmed-105130212023-09-22 Impact of consuming a Mediterranean-style diet during pregnancy on neurodevelopmental disabilities in offspring: results from the Boston Birth Cohort Che, Xiaoyu Gross, Susan M. Wang, Guoying Hong, Xiumei Pearson, Colleen Bartell, Tami Wang, Xiaobin Precis Nutr Original Study BACKGROUND: While consuming a Mediterranean-style diet (MSD) among pregnant women is expected to affect offspring neurodevelopment, the current evidence is limited. This prospective birth cohort study aimed to explore the association of maternal MSD with neurodevelopmental disabilities (NDD) in offspring, especially among children born to mothers with overweight or obesity (OWO) and/or diabetes mellitus (DM) since they have a higher risk for oxidative stress and immune/metabolic disturbances. METHODS: We analyzed data from a subgroup of mother–child dyads enrolled in the Boston Birth Cohort. Maternal dietary information (via food frequency questionnaires, Food frequency questionnaires [FFQ]) and sociodemographic information were obtained via in-person interviews within 24 to 72 hours postpartum. Maternal clinical information and child diagnosis of NDD including autism, attention-deficit/hyperactivity disorder (ADHD), and other developmental disabilities (DD) were extracted from medical records. A Mediterranean-style diet score (MSDS) was calculated using the FFQ. The association of maternal MSDS with NDD, autism, ADHD, and other DD was evaluated using multivariable logistic regression models adjusted for pertinent covariates. RESULTS: This study included 3153 mother–child pairs, from which we identified diagnoses of 1362 (43.2%) NDD, including 123 (3.9%) case of autism, 445 (14.1%) ADHD, and 794 (25.2%) other DD. In the overall sample, women with a higher maternal MSDS (per standard deviation increase) were less likely to have offspring with NDD (adjusted odds ratio [OR]: 0.904, 95% confidence interval [CI]: 0.817–1.000; P value: 0.049). Using MSDS quintile 1 as the reference, being in the combined group of quintiles 3–5 was associated with a 26% lower likelihood of NDD (adjusted OR: 0.738, 95% CI: 0.572–0.951; P value: 0.019). When stratified by mothers with OWO/DM vs. without OWO/DM, the association between maternal MSDS and offspring NDD was greater in children born to mothers with OWO/DM. CONCLUSIONS: In this prospective birth cohort, a higher maternal MSDS was associated with a lower likelihood of NDD in the offspring. Furthermore, this association of maternal MSDS with offspring NDD was greater in children born to women with OWO/DM. More studies are needed to replicate the findings and further analyze NDD subgroups and explore underlying molecular pathways. Lippincott Williams & Wilkins 2023-07-11 /pmc/articles/PMC10513021/ /pubmed/37744413 http://dx.doi.org/10.1097/PN9.0000000000000047 Text en Copyright © 2023 The Author(s), Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Study
Che, Xiaoyu
Gross, Susan M.
Wang, Guoying
Hong, Xiumei
Pearson, Colleen
Bartell, Tami
Wang, Xiaobin
Impact of consuming a Mediterranean-style diet during pregnancy on neurodevelopmental disabilities in offspring: results from the Boston Birth Cohort
title Impact of consuming a Mediterranean-style diet during pregnancy on neurodevelopmental disabilities in offspring: results from the Boston Birth Cohort
title_full Impact of consuming a Mediterranean-style diet during pregnancy on neurodevelopmental disabilities in offspring: results from the Boston Birth Cohort
title_fullStr Impact of consuming a Mediterranean-style diet during pregnancy on neurodevelopmental disabilities in offspring: results from the Boston Birth Cohort
title_full_unstemmed Impact of consuming a Mediterranean-style diet during pregnancy on neurodevelopmental disabilities in offspring: results from the Boston Birth Cohort
title_short Impact of consuming a Mediterranean-style diet during pregnancy on neurodevelopmental disabilities in offspring: results from the Boston Birth Cohort
title_sort impact of consuming a mediterranean-style diet during pregnancy on neurodevelopmental disabilities in offspring: results from the boston birth cohort
topic Original Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513021/
https://www.ncbi.nlm.nih.gov/pubmed/37744413
http://dx.doi.org/10.1097/PN9.0000000000000047
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