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Establishing induced pluripotent stem cell lines from two dominant optic atrophy patients with distinct OPA1 mutations and clinical pathologies

Dominant optic atrophy (DOA) is an inherited disease that leads to the loss of retinal ganglion cells (RGCs), the projection neurons that relay visual information from the retina to the brain through the optic nerve. The majority of DOA cases can be attributed to mutations in optic atrophy 1 (OPA1),...

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Detalles Bibliográficos
Autores principales:	Pohl, Katherine A., Zhang, Xiangmei, Pham, Anh H., Chan, Jane W., Sadun, Alfredo A., Yang, Xian-Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513078/ https://www.ncbi.nlm.nih.gov/pubmed/37745862 http://dx.doi.org/10.3389/fgene.2023.1251216

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