Cargando…

The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases

The pathophysiology of different neurodegenerative illnesses is significantly influenced by the polarization regulation of microglia and macrophages. Traditional classifications of macrophage phenotypes include the pro-inflammatory M1 and the anti-inflammatory M2 phenotypes. Numerous studies demonst...

Descripción completa

Detalles Bibliográficos
Autores principales: Darwish, Samar F., Elbadry, Abdullah M. M., Elbokhomy, Amir S., Salama, Ghidaa A., Salama, Rania M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513083/
https://www.ncbi.nlm.nih.gov/pubmed/37744008
http://dx.doi.org/10.3389/fragi.2023.1231706
_version_ 1785108490995367936
author Darwish, Samar F.
Elbadry, Abdullah M. M.
Elbokhomy, Amir S.
Salama, Ghidaa A.
Salama, Rania M.
author_facet Darwish, Samar F.
Elbadry, Abdullah M. M.
Elbokhomy, Amir S.
Salama, Ghidaa A.
Salama, Rania M.
author_sort Darwish, Samar F.
collection PubMed
description The pathophysiology of different neurodegenerative illnesses is significantly influenced by the polarization regulation of microglia and macrophages. Traditional classifications of macrophage phenotypes include the pro-inflammatory M1 and the anti-inflammatory M2 phenotypes. Numerous studies demonstrated dynamic non-coding RNA modifications, which are catalyzed by microglia-induced neuroinflammation. Different nutraceuticals focus on the polarization of M1/M2 phenotypes of microglia and macrophages, offering a potent defense against neurodegeneration. Caeminaxin A, curcumin, aromatic-turmerone, myricetin, aurantiamide, 3,6′-disinapoylsucrose, and resveratrol reduced M1 microglial inflammatory markers while increased M2 indicators in Alzheimer’s disease. Amyloid beta-induced microglial M1 activation was suppressed by andrographolide, sulforaphane, triptolide, xanthoceraside, piperlongumine, and novel plant extracts which also prevented microglia-mediated necroptosis and apoptosis. Asarone, galangin, baicalein, and a-mangostin reduced oxidative stress and pro-inflammatory cytokines, such as interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha in M1-activated microglia in Parkinson’s disease. Additionally, myrcene, icariin, and tenuigenin prevented the nod-like receptor family pyrin domain-containing 3 inflammasome and microglial neurotoxicity, while a-cyperone, citronellol, nobiletin, and taurine prevented NADPH oxidase 2 and nuclear factor kappa B activation. Furthermore, other nutraceuticals like plantamajoside, swertiamarin, urolithin A, kurarinone, Daphne genkwa flower, and Boswellia serrata extracts showed promising neuroprotection in treating Parkinson’s disease. In Huntington’s disease, elderberry, curcumin, iresine celosia, Schisandra chinensis, gintonin, and pomiferin showed promising results against microglial activation and improved patient symptoms. Meanwhile, linolenic acid, resveratrol, Huperzia serrata, icariin, and baicalein protected against activated macrophages and microglia in experimental autoimmune encephalomyelitis and multiple sclerosis. Additionally, emodin, esters of gallic and rosmarinic acids, Agathisflavone, and sinomenine offered promising multiple sclerosis treatments. This review highlights the therapeutic potential of using nutraceuticals to treat neurodegenerative diseases involving microglial-related pathways.
format Online
Article
Text
id pubmed-10513083
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-105130832023-09-22 The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases Darwish, Samar F. Elbadry, Abdullah M. M. Elbokhomy, Amir S. Salama, Ghidaa A. Salama, Rania M. Front Aging Aging The pathophysiology of different neurodegenerative illnesses is significantly influenced by the polarization regulation of microglia and macrophages. Traditional classifications of macrophage phenotypes include the pro-inflammatory M1 and the anti-inflammatory M2 phenotypes. Numerous studies demonstrated dynamic non-coding RNA modifications, which are catalyzed by microglia-induced neuroinflammation. Different nutraceuticals focus on the polarization of M1/M2 phenotypes of microglia and macrophages, offering a potent defense against neurodegeneration. Caeminaxin A, curcumin, aromatic-turmerone, myricetin, aurantiamide, 3,6′-disinapoylsucrose, and resveratrol reduced M1 microglial inflammatory markers while increased M2 indicators in Alzheimer’s disease. Amyloid beta-induced microglial M1 activation was suppressed by andrographolide, sulforaphane, triptolide, xanthoceraside, piperlongumine, and novel plant extracts which also prevented microglia-mediated necroptosis and apoptosis. Asarone, galangin, baicalein, and a-mangostin reduced oxidative stress and pro-inflammatory cytokines, such as interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha in M1-activated microglia in Parkinson’s disease. Additionally, myrcene, icariin, and tenuigenin prevented the nod-like receptor family pyrin domain-containing 3 inflammasome and microglial neurotoxicity, while a-cyperone, citronellol, nobiletin, and taurine prevented NADPH oxidase 2 and nuclear factor kappa B activation. Furthermore, other nutraceuticals like plantamajoside, swertiamarin, urolithin A, kurarinone, Daphne genkwa flower, and Boswellia serrata extracts showed promising neuroprotection in treating Parkinson’s disease. In Huntington’s disease, elderberry, curcumin, iresine celosia, Schisandra chinensis, gintonin, and pomiferin showed promising results against microglial activation and improved patient symptoms. Meanwhile, linolenic acid, resveratrol, Huperzia serrata, icariin, and baicalein protected against activated macrophages and microglia in experimental autoimmune encephalomyelitis and multiple sclerosis. Additionally, emodin, esters of gallic and rosmarinic acids, Agathisflavone, and sinomenine offered promising multiple sclerosis treatments. This review highlights the therapeutic potential of using nutraceuticals to treat neurodegenerative diseases involving microglial-related pathways. Frontiers Media S.A. 2023-09-06 /pmc/articles/PMC10513083/ /pubmed/37744008 http://dx.doi.org/10.3389/fragi.2023.1231706 Text en Copyright © 2023 Darwish, Elbadry, Elbokhomy, Salama and Salama. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Darwish, Samar F.
Elbadry, Abdullah M. M.
Elbokhomy, Amir S.
Salama, Ghidaa A.
Salama, Rania M.
The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases
title The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases
title_full The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases
title_fullStr The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases
title_full_unstemmed The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases
title_short The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases
title_sort dual face of microglia (m1/m2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513083/
https://www.ncbi.nlm.nih.gov/pubmed/37744008
http://dx.doi.org/10.3389/fragi.2023.1231706
work_keys_str_mv AT darwishsamarf thedualfaceofmicrogliam1m2asapotentialtargetintheprotectiveeffectofnutraceuticalsagainstneurodegenerativediseases
AT elbadryabdullahmm thedualfaceofmicrogliam1m2asapotentialtargetintheprotectiveeffectofnutraceuticalsagainstneurodegenerativediseases
AT elbokhomyamirs thedualfaceofmicrogliam1m2asapotentialtargetintheprotectiveeffectofnutraceuticalsagainstneurodegenerativediseases
AT salamaghidaaa thedualfaceofmicrogliam1m2asapotentialtargetintheprotectiveeffectofnutraceuticalsagainstneurodegenerativediseases
AT salamaraniam thedualfaceofmicrogliam1m2asapotentialtargetintheprotectiveeffectofnutraceuticalsagainstneurodegenerativediseases
AT darwishsamarf dualfaceofmicrogliam1m2asapotentialtargetintheprotectiveeffectofnutraceuticalsagainstneurodegenerativediseases
AT elbadryabdullahmm dualfaceofmicrogliam1m2asapotentialtargetintheprotectiveeffectofnutraceuticalsagainstneurodegenerativediseases
AT elbokhomyamirs dualfaceofmicrogliam1m2asapotentialtargetintheprotectiveeffectofnutraceuticalsagainstneurodegenerativediseases
AT salamaghidaaa dualfaceofmicrogliam1m2asapotentialtargetintheprotectiveeffectofnutraceuticalsagainstneurodegenerativediseases
AT salamaraniam dualfaceofmicrogliam1m2asapotentialtargetintheprotectiveeffectofnutraceuticalsagainstneurodegenerativediseases