Plasma cortisol-linked gene networks in hepatic and adipose tissues implicate corticosteroid-binding globulin in modulating tissue glucocorticoid action and cardiovascular risk

Genome-wide association meta-analysis (GWAMA) by the Cortisol Network (CORNET) consortium identified genetic variants spanning the SERPINA6/SERPINA1 locus on chromosome 14 associated with morning plasma cortisol, cardiovascular disease (CVD), and SERPINA6 mRNA expression encoding corticosteroid-bind...

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Detalles Bibliográficos
Autores principales: Bankier, Sean, Wang, Lingfei, Crawford, Andrew, Morgan, Ruth A., Ruusalepp, Arno, Andrew, Ruth, Björkegren, Johan L. M., Walker, Brian R., Michoel, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513085/
https://www.ncbi.nlm.nih.gov/pubmed/37745713
http://dx.doi.org/10.3389/fendo.2023.1186252

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