The mechanisms and factors that induce trained immunity in arthropods and mollusks

Besides dividing the organism’s immune system into adaptive and innate immunity, it has long been thought that only adaptive immunity can establish immune memory. However, many studies have shown that innate immunity can also build immunological memory through epigenetic reprogramming and modificati...

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Autores principales: Zhao, Mingming, Lin, Zhongyang, Zheng, Zhihong, Yao, Defu, Yang, Shen, Zhao, Yongzhen, Chen, Xiuli, Aweya, Jude Juventus, Zhang, Yueling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513178/
https://www.ncbi.nlm.nih.gov/pubmed/37744346
http://dx.doi.org/10.3389/fimmu.2023.1241934
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author Zhao, Mingming
Lin, Zhongyang
Zheng, Zhihong
Yao, Defu
Yang, Shen
Zhao, Yongzhen
Chen, Xiuli
Aweya, Jude Juventus
Zhang, Yueling
author_facet Zhao, Mingming
Lin, Zhongyang
Zheng, Zhihong
Yao, Defu
Yang, Shen
Zhao, Yongzhen
Chen, Xiuli
Aweya, Jude Juventus
Zhang, Yueling
author_sort Zhao, Mingming
collection PubMed
description Besides dividing the organism’s immune system into adaptive and innate immunity, it has long been thought that only adaptive immunity can establish immune memory. However, many studies have shown that innate immunity can also build immunological memory through epigenetic reprogramming and modifications to resist pathogens’ reinfection, known as trained immunity. This paper reviews the role of mitochondrial metabolism and epigenetic modifications and describes the molecular foundation in the trained immunity of arthropods and mollusks. Mitochondrial metabolism and epigenetic modifications complement each other and play a key role in trained immunity.
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spelling pubmed-105131782023-09-22 The mechanisms and factors that induce trained immunity in arthropods and mollusks Zhao, Mingming Lin, Zhongyang Zheng, Zhihong Yao, Defu Yang, Shen Zhao, Yongzhen Chen, Xiuli Aweya, Jude Juventus Zhang, Yueling Front Immunol Immunology Besides dividing the organism’s immune system into adaptive and innate immunity, it has long been thought that only adaptive immunity can establish immune memory. However, many studies have shown that innate immunity can also build immunological memory through epigenetic reprogramming and modifications to resist pathogens’ reinfection, known as trained immunity. This paper reviews the role of mitochondrial metabolism and epigenetic modifications and describes the molecular foundation in the trained immunity of arthropods and mollusks. Mitochondrial metabolism and epigenetic modifications complement each other and play a key role in trained immunity. Frontiers Media S.A. 2023-09-07 /pmc/articles/PMC10513178/ /pubmed/37744346 http://dx.doi.org/10.3389/fimmu.2023.1241934 Text en Copyright © 2023 Zhao, Lin, Zheng, Yao, Yang, Zhao, Chen, Aweya and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhao, Mingming
Lin, Zhongyang
Zheng, Zhihong
Yao, Defu
Yang, Shen
Zhao, Yongzhen
Chen, Xiuli
Aweya, Jude Juventus
Zhang, Yueling
The mechanisms and factors that induce trained immunity in arthropods and mollusks
title The mechanisms and factors that induce trained immunity in arthropods and mollusks
title_full The mechanisms and factors that induce trained immunity in arthropods and mollusks
title_fullStr The mechanisms and factors that induce trained immunity in arthropods and mollusks
title_full_unstemmed The mechanisms and factors that induce trained immunity in arthropods and mollusks
title_short The mechanisms and factors that induce trained immunity in arthropods and mollusks
title_sort mechanisms and factors that induce trained immunity in arthropods and mollusks
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513178/
https://www.ncbi.nlm.nih.gov/pubmed/37744346
http://dx.doi.org/10.3389/fimmu.2023.1241934
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