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Near-term pregnant women in the Dominican Republic experience high rates of Group B Streptococcus rectovaginal colonization with virulent strains

Maternal colonization with Group B Streptococcus (GBS) is an important cause of stillbirth, prematurity, and serious infection and death in infants worldwide. Resource constraints limit prevention strategies in many regions. Maternal GBS vaccines in development could be a more accessible prevention...

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Autores principales: Laycock, Katherine M., Acosta, Francia, Valera, Sandra, Villegas, Ana, Mejia, Elia, Mateo, Christian, Felipe, Rosa, Fernández, Anabel, Job, Megan, Dongas, Sophia, Steenhoff, Andrew P., Ratner, Adam J., Geoghegan, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513192/
https://www.ncbi.nlm.nih.gov/pubmed/37733668
http://dx.doi.org/10.1371/journal.pgph.0002281
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author Laycock, Katherine M.
Acosta, Francia
Valera, Sandra
Villegas, Ana
Mejia, Elia
Mateo, Christian
Felipe, Rosa
Fernández, Anabel
Job, Megan
Dongas, Sophia
Steenhoff, Andrew P.
Ratner, Adam J.
Geoghegan, Sarah
author_facet Laycock, Katherine M.
Acosta, Francia
Valera, Sandra
Villegas, Ana
Mejia, Elia
Mateo, Christian
Felipe, Rosa
Fernández, Anabel
Job, Megan
Dongas, Sophia
Steenhoff, Andrew P.
Ratner, Adam J.
Geoghegan, Sarah
author_sort Laycock, Katherine M.
collection PubMed
description Maternal colonization with Group B Streptococcus (GBS) is an important cause of stillbirth, prematurity, and serious infection and death in infants worldwide. Resource constraints limit prevention strategies in many regions. Maternal GBS vaccines in development could be a more accessible prevention strategy, but data on geographic variations in GBS clones are needed to guide development of a broadly effective vaccine. In the Dominican Republic (DR), limited data suggest that pregnant women experience GBS colonization at rates among the highest globally. We aimed to determine the prevalence of maternal rectovaginal GBS colonization and describe clonal characteristics of colonizing strains in the DR. A cross-sectional study assessed rectovaginal GBS colonization in 350 near-term pregnant women presenting for routine prenatal care at an urban tertiary center in the DR. Rectovaginal samples were tested with chromogenic Strep B Carrot Broth and cultured for confirmatory whole-genome sequencing. In a secondary analysis, participants’ demographics and histories were assessed for association with GBS colonization. Rectovaginal GBS colonization occurred in 26.6% of women. Serotypes Ia, Ib, II, III, IV, and V were detected, with no one serotype predominating; serotype III was identified most frequently (21.5%). Virulent and emerging strains were common, including CC17 (15.1%) and ST1010 (17.2%). In this first characterization of maternal GBS serotypes in the DR, we found high rates of rectovaginal colonization including with virulent and emerging GBS strains. The serotypes observed here are all targeted by candidate hexavalent GBS vaccines, suggesting effective protection in the DR.
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spelling pubmed-105131922023-09-22 Near-term pregnant women in the Dominican Republic experience high rates of Group B Streptococcus rectovaginal colonization with virulent strains Laycock, Katherine M. Acosta, Francia Valera, Sandra Villegas, Ana Mejia, Elia Mateo, Christian Felipe, Rosa Fernández, Anabel Job, Megan Dongas, Sophia Steenhoff, Andrew P. Ratner, Adam J. Geoghegan, Sarah PLOS Glob Public Health Research Article Maternal colonization with Group B Streptococcus (GBS) is an important cause of stillbirth, prematurity, and serious infection and death in infants worldwide. Resource constraints limit prevention strategies in many regions. Maternal GBS vaccines in development could be a more accessible prevention strategy, but data on geographic variations in GBS clones are needed to guide development of a broadly effective vaccine. In the Dominican Republic (DR), limited data suggest that pregnant women experience GBS colonization at rates among the highest globally. We aimed to determine the prevalence of maternal rectovaginal GBS colonization and describe clonal characteristics of colonizing strains in the DR. A cross-sectional study assessed rectovaginal GBS colonization in 350 near-term pregnant women presenting for routine prenatal care at an urban tertiary center in the DR. Rectovaginal samples were tested with chromogenic Strep B Carrot Broth and cultured for confirmatory whole-genome sequencing. In a secondary analysis, participants’ demographics and histories were assessed for association with GBS colonization. Rectovaginal GBS colonization occurred in 26.6% of women. Serotypes Ia, Ib, II, III, IV, and V were detected, with no one serotype predominating; serotype III was identified most frequently (21.5%). Virulent and emerging strains were common, including CC17 (15.1%) and ST1010 (17.2%). In this first characterization of maternal GBS serotypes in the DR, we found high rates of rectovaginal colonization including with virulent and emerging GBS strains. The serotypes observed here are all targeted by candidate hexavalent GBS vaccines, suggesting effective protection in the DR. Public Library of Science 2023-09-21 /pmc/articles/PMC10513192/ /pubmed/37733668 http://dx.doi.org/10.1371/journal.pgph.0002281 Text en © 2023 Laycock et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Laycock, Katherine M.
Acosta, Francia
Valera, Sandra
Villegas, Ana
Mejia, Elia
Mateo, Christian
Felipe, Rosa
Fernández, Anabel
Job, Megan
Dongas, Sophia
Steenhoff, Andrew P.
Ratner, Adam J.
Geoghegan, Sarah
Near-term pregnant women in the Dominican Republic experience high rates of Group B Streptococcus rectovaginal colonization with virulent strains
title Near-term pregnant women in the Dominican Republic experience high rates of Group B Streptococcus rectovaginal colonization with virulent strains
title_full Near-term pregnant women in the Dominican Republic experience high rates of Group B Streptococcus rectovaginal colonization with virulent strains
title_fullStr Near-term pregnant women in the Dominican Republic experience high rates of Group B Streptococcus rectovaginal colonization with virulent strains
title_full_unstemmed Near-term pregnant women in the Dominican Republic experience high rates of Group B Streptococcus rectovaginal colonization with virulent strains
title_short Near-term pregnant women in the Dominican Republic experience high rates of Group B Streptococcus rectovaginal colonization with virulent strains
title_sort near-term pregnant women in the dominican republic experience high rates of group b streptococcus rectovaginal colonization with virulent strains
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513192/
https://www.ncbi.nlm.nih.gov/pubmed/37733668
http://dx.doi.org/10.1371/journal.pgph.0002281
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