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Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment

T cells are an important component of adaptive immunity and T-cell-derived lymphomas are very complex due to many functional sub-types and functional elasticity of T-cells. As with other tumors, tissues specific factors are crucial in the development of T-cell lymphomas. In addition to neoplastic ce...

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Autores principales: Yadav, Megha, Uikey, Blessi N., Rathore, Shantnu Singh, Gupta, Priyanka, Kashyap, Diksha, Kumar, Chanchal, Shukla, Dhananjay, Vijayamahantesh, Chandel, Arvind Singh, Ahirwar, Bharti, Singh, Ashish Kumar, Suman, Shashi Shekhar, Priyadarshi, Amit, Amit, Ajay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513393/
https://www.ncbi.nlm.nih.gov/pubmed/37746258
http://dx.doi.org/10.3389/fonc.2023.1235711
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author Yadav, Megha
Uikey, Blessi N.
Rathore, Shantnu Singh
Gupta, Priyanka
Kashyap, Diksha
Kumar, Chanchal
Shukla, Dhananjay
Vijayamahantesh
Chandel, Arvind Singh
Ahirwar, Bharti
Singh, Ashish Kumar
Suman, Shashi Shekhar
Priyadarshi, Amit
Amit, Ajay
author_facet Yadav, Megha
Uikey, Blessi N.
Rathore, Shantnu Singh
Gupta, Priyanka
Kashyap, Diksha
Kumar, Chanchal
Shukla, Dhananjay
Vijayamahantesh
Chandel, Arvind Singh
Ahirwar, Bharti
Singh, Ashish Kumar
Suman, Shashi Shekhar
Priyadarshi, Amit
Amit, Ajay
author_sort Yadav, Megha
collection PubMed
description T cells are an important component of adaptive immunity and T-cell-derived lymphomas are very complex due to many functional sub-types and functional elasticity of T-cells. As with other tumors, tissues specific factors are crucial in the development of T-cell lymphomas. In addition to neoplastic cells, T- cell lymphomas consist of a tumor micro-environment composed of normal cells and stroma. Numerous studies established the qualitative and quantitative differences between the tumor microenvironment and normal cell surroundings. Interaction between the various component of the tumor microenvironment is crucial since tumor cells can change the microenvironment and vice versa. In normal T-cell development, T-cells must respond to various stimulants deferentially and during these courses of adaptation. T-cells undergo various metabolic alterations. From the stage of quiescence to attention of fully active form T-cells undergoes various stage in terms of metabolic activity. Predominantly quiescent T-cells have ATP-generating metabolism while during the proliferative stage, their metabolism tilted towards the growth-promoting pathways. In addition to this, a functionally different subset of T-cells requires to activate the different metabolic pathways, and consequently, this regulation of the metabolic pathway control activation and function of T-cells. So, it is obvious that dynamic, and well-regulated metabolic pathways are important for the normal functioning of T-cells and their interaction with the microenvironment. There are various cell signaling mechanisms of metabolism are involved in this regulation and more and more studies have suggested the involvement of additional signaling in the development of the overall metabolic phenotype of T cells. These important signaling mediators include cytokines and hormones. The impact and role of these mediators especially the cytokines on the interplay between T-cell metabolism and the interaction of T-cells with their micro-environments in the context of T-cells lymphomas are discussed in this review article.
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spelling pubmed-105133932023-09-22 Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment Yadav, Megha Uikey, Blessi N. Rathore, Shantnu Singh Gupta, Priyanka Kashyap, Diksha Kumar, Chanchal Shukla, Dhananjay Vijayamahantesh Chandel, Arvind Singh Ahirwar, Bharti Singh, Ashish Kumar Suman, Shashi Shekhar Priyadarshi, Amit Amit, Ajay Front Oncol Oncology T cells are an important component of adaptive immunity and T-cell-derived lymphomas are very complex due to many functional sub-types and functional elasticity of T-cells. As with other tumors, tissues specific factors are crucial in the development of T-cell lymphomas. In addition to neoplastic cells, T- cell lymphomas consist of a tumor micro-environment composed of normal cells and stroma. Numerous studies established the qualitative and quantitative differences between the tumor microenvironment and normal cell surroundings. Interaction between the various component of the tumor microenvironment is crucial since tumor cells can change the microenvironment and vice versa. In normal T-cell development, T-cells must respond to various stimulants deferentially and during these courses of adaptation. T-cells undergo various metabolic alterations. From the stage of quiescence to attention of fully active form T-cells undergoes various stage in terms of metabolic activity. Predominantly quiescent T-cells have ATP-generating metabolism while during the proliferative stage, their metabolism tilted towards the growth-promoting pathways. In addition to this, a functionally different subset of T-cells requires to activate the different metabolic pathways, and consequently, this regulation of the metabolic pathway control activation and function of T-cells. So, it is obvious that dynamic, and well-regulated metabolic pathways are important for the normal functioning of T-cells and their interaction with the microenvironment. There are various cell signaling mechanisms of metabolism are involved in this regulation and more and more studies have suggested the involvement of additional signaling in the development of the overall metabolic phenotype of T cells. These important signaling mediators include cytokines and hormones. The impact and role of these mediators especially the cytokines on the interplay between T-cell metabolism and the interaction of T-cells with their micro-environments in the context of T-cells lymphomas are discussed in this review article. Frontiers Media S.A. 2023-09-07 /pmc/articles/PMC10513393/ /pubmed/37746258 http://dx.doi.org/10.3389/fonc.2023.1235711 Text en Copyright © 2023 Yadav, Uikey, Rathore, Gupta, Kashyap, Kumar, Shukla, Vijayamahantesh, Chandel, Ahirwar, Singh, Suman, Priyadarshi and Amit https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yadav, Megha
Uikey, Blessi N.
Rathore, Shantnu Singh
Gupta, Priyanka
Kashyap, Diksha
Kumar, Chanchal
Shukla, Dhananjay
Vijayamahantesh
Chandel, Arvind Singh
Ahirwar, Bharti
Singh, Ashish Kumar
Suman, Shashi Shekhar
Priyadarshi, Amit
Amit, Ajay
Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment
title Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment
title_full Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment
title_fullStr Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment
title_full_unstemmed Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment
title_short Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment
title_sort role of cytokine in malignant t-cell metabolism and subsequent alternation in t-cell tumor microenvironment
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513393/
https://www.ncbi.nlm.nih.gov/pubmed/37746258
http://dx.doi.org/10.3389/fonc.2023.1235711
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