Camouflaged angiogenic BMP-2 functions exposed by pico-paracrine biohybrids

The constant release of human bone morphogenetic protein 2 (rhBMP-2) in the picomolar range (Pico-Stat) from PDLLA-biohybrids led to the detection of intrinsic novel pro- and anti-angiogenic functions of this cytokine. As integrant part in this perspective of previous work, first evidence for the bi...

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Detalles Bibliográficos
Autor principal: Jennissen, Herbert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513495/
https://www.ncbi.nlm.nih.gov/pubmed/37744249
http://dx.doi.org/10.3389/fbioe.2023.1226649
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author Jennissen, Herbert P.
author_facet Jennissen, Herbert P.
author_sort Jennissen, Herbert P.
collection PubMed
description The constant release of human bone morphogenetic protein 2 (rhBMP-2) in the picomolar range (Pico-Stat) from PDLLA-biohybrids led to the detection of intrinsic novel pro- and anti-angiogenic functions of this cytokine. As integrant part in this perspective of previous work, first evidence for the binding of rhBMP-2, as an inverse agonist, to allosteric angiogenic receptors in cocultures of human endothelial cells is reported.
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spelling pubmed-105134952023-09-22 Camouflaged angiogenic BMP-2 functions exposed by pico-paracrine biohybrids Jennissen, Herbert P. Front Bioeng Biotechnol Bioengineering and Biotechnology The constant release of human bone morphogenetic protein 2 (rhBMP-2) in the picomolar range (Pico-Stat) from PDLLA-biohybrids led to the detection of intrinsic novel pro- and anti-angiogenic functions of this cytokine. As integrant part in this perspective of previous work, first evidence for the binding of rhBMP-2, as an inverse agonist, to allosteric angiogenic receptors in cocultures of human endothelial cells is reported. Frontiers Media S.A. 2023-09-07 /pmc/articles/PMC10513495/ /pubmed/37744249 http://dx.doi.org/10.3389/fbioe.2023.1226649 Text en Copyright © 2023 Jennissen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Jennissen, Herbert P.
Camouflaged angiogenic BMP-2 functions exposed by pico-paracrine biohybrids
title Camouflaged angiogenic BMP-2 functions exposed by pico-paracrine biohybrids
title_full Camouflaged angiogenic BMP-2 functions exposed by pico-paracrine biohybrids
title_fullStr Camouflaged angiogenic BMP-2 functions exposed by pico-paracrine biohybrids
title_full_unstemmed Camouflaged angiogenic BMP-2 functions exposed by pico-paracrine biohybrids
title_short Camouflaged angiogenic BMP-2 functions exposed by pico-paracrine biohybrids
title_sort camouflaged angiogenic bmp-2 functions exposed by pico-paracrine biohybrids
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513495/
https://www.ncbi.nlm.nih.gov/pubmed/37744249
http://dx.doi.org/10.3389/fbioe.2023.1226649
work_keys_str_mv AT jennissenherbertp camouflagedangiogenicbmp2functionsexposedbypicoparacrinebiohybrids

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