High frequency of WNT-activated medulloblastomas with CTNNB1 wild type suggests a higher proportion of hereditary cases in a Latin-Iberian population

PURPOSE: Medulloblastomas are the most common primary malignant brain tumors in children. They are divided into molecular subgroups: WNT-activated, SHH-Activated, TP53 mutant or wild type, and non-WNT/non-SHH (Groups 3 and 4). WNT-activated medulloblastomas are usually caused by mutations in the CTN...

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Detalles Bibliográficos
Autores principales: Moreno, Daniel Antunes, Bonatelli, Murilo, Antoniazzi, Augusto Perazzolo, de Paula, Flávia Escremim, Leal, Leticia Ferro, Garcia, Felipe Antônio de Oliveira, de Paula, André Escremim, Teixeira, Gustavo Ramos, Santana, Iara Viana Vidigal, Saggioro, Fabiano, Neder, Luciano, Valera, Elvis Terci, Scrideli, Carlos Alberto, Stavale, João, Malheiros, Suzana Maria Fleury, Lima, Matheus, Hajj, Glaucia Noeli Maroso, Garcia-Rivello, Hernan, Christiansen, Silvia, Nunes, Susana, Gil-da-Costa, Maria João, Pinheiro, Jorge, Martins, Flavia Delgado, Junior, Carlos Almeida, Mançano, Bruna Minniti, Reis, Rui Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513896/
https://www.ncbi.nlm.nih.gov/pubmed/37746264
http://dx.doi.org/10.3389/fonc.2023.1237170

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