Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy

Resistance of melanoma to targeted therapy and immunotherapy is linked to metabolic rewiring. Here, we show that increased fatty acid oxidation (FAO) during prolonged BRAF inhibitor (BRAFi) treatment contributes to acquired therapy resistance in mice. Targeting FAO using the US Food and Drug Adminis...

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Detalles Bibliográficos
Autores principales: Redondo-Muñoz, Marta, Rodriguez-Baena, Francisco Javier, Aldaz, Paula, Caballé-Mestres, Adriá, Moncho-Amor, Verónica, Otaegi-Ugartemendia, Maddalen, Carrasco-Garcia, Estefania, Olias-Arjona, Ana, Lasheras-Otero, Irene, Santamaria, Eva, Bocanegra, Ana, Chocarro, Luisa, Grier, Abby, Dzieciatkowska M, Monika, Bigas, Claudia, Martin, Josefina, Urdiroz-Urricelqui, Uxue, Marzo, Florencio, Santamaria, Enrique, Kochan, Grazyna, Escors, David, Larrayoz, Ignacio Marcos, Heyn, Holger, D’Alessandro, Angelo, Attolini, Camille Stephan-Otto, Matheu, Ander, Wellbrock, Claudia, Benitah, Salvador Aznar, Sanchez-Laorden, Berta, Arozarena, Imanol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513932/
https://www.ncbi.nlm.nih.gov/pubmed/37563469
http://dx.doi.org/10.1038/s42255-023-00861-4

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