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CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway

Non-small cell lung cancer (NSCLC) is a highly lethal cancer, and better treatments are urgently needed. Many studies have implicated circular RNAs (circRNAs) in the progression of multiple malignant tumors. Nonetheless, the functions of circRNAs in NSCLC remain unclear. To study new targets for the...

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Autores principales: DU, WEI, YIN, FANG, ZHONG, YATING, LUO, MINJIE, WANG, ZHEN, LIN, PENG, LIU, QING, YANG, HAN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tech Science Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513941/
https://www.ncbi.nlm.nih.gov/pubmed/37744277
http://dx.doi.org/10.32604/or.2023.030611
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author DU, WEI
YIN, FANG
ZHONG, YATING
LUO, MINJIE
WANG, ZHEN
LIN, PENG
LIU, QING
YANG, HAN
author_facet DU, WEI
YIN, FANG
ZHONG, YATING
LUO, MINJIE
WANG, ZHEN
LIN, PENG
LIU, QING
YANG, HAN
author_sort DU, WEI
collection PubMed
description Non-small cell lung cancer (NSCLC) is a highly lethal cancer, and better treatments are urgently needed. Many studies have implicated circular RNAs (circRNAs) in the progression of multiple malignant tumors. Nonetheless, the functions of circRNAs in NSCLC remain unclear. To study new targets for the treatment of NSCLC, circRNA expression profiling was performed on NSCLC tissues and para-carcinoma nonmalignant tissues. RNA was isolated and used for circRNA sequencing. Biological studies were performed in vitro and in vivo to determine the functions of circRNAs in NSCLC, including their functions in cell proliferation and migration. How circRNAs function in NSCLC was explored to clarify the underlying regulatory mechanisms. We found that circUCP2 was upregulated in NSCLC tissues compared with neighboring nonmalignant tissues. circUCP2 promoted the proliferation and metastasis of NSCLC cells. circUCP2 promoted NSCLC progression by sponging miR-149 and upregulating UCP2. The circUCP2/miR-149/UCP2 axis accelerates the progression of NSCLC, and circUCP2 may therefore be a novel diagnostic biomarker for the progression of NSCLC.
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spelling pubmed-105139412023-09-23 CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway DU, WEI YIN, FANG ZHONG, YATING LUO, MINJIE WANG, ZHEN LIN, PENG LIU, QING YANG, HAN Oncol Res Article Non-small cell lung cancer (NSCLC) is a highly lethal cancer, and better treatments are urgently needed. Many studies have implicated circular RNAs (circRNAs) in the progression of multiple malignant tumors. Nonetheless, the functions of circRNAs in NSCLC remain unclear. To study new targets for the treatment of NSCLC, circRNA expression profiling was performed on NSCLC tissues and para-carcinoma nonmalignant tissues. RNA was isolated and used for circRNA sequencing. Biological studies were performed in vitro and in vivo to determine the functions of circRNAs in NSCLC, including their functions in cell proliferation and migration. How circRNAs function in NSCLC was explored to clarify the underlying regulatory mechanisms. We found that circUCP2 was upregulated in NSCLC tissues compared with neighboring nonmalignant tissues. circUCP2 promoted the proliferation and metastasis of NSCLC cells. circUCP2 promoted NSCLC progression by sponging miR-149 and upregulating UCP2. The circUCP2/miR-149/UCP2 axis accelerates the progression of NSCLC, and circUCP2 may therefore be a novel diagnostic biomarker for the progression of NSCLC. Tech Science Press 2023-09-15 /pmc/articles/PMC10513941/ /pubmed/37744277 http://dx.doi.org/10.32604/or.2023.030611 Text en © 2023 Du et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
DU, WEI
YIN, FANG
ZHONG, YATING
LUO, MINJIE
WANG, ZHEN
LIN, PENG
LIU, QING
YANG, HAN
CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway
title CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway
title_full CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway
title_fullStr CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway
title_full_unstemmed CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway
title_short CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway
title_sort circucp2 promotes the tumor progression of non-small cell lung cancer through the mir-149/ucp2 pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513941/
https://www.ncbi.nlm.nih.gov/pubmed/37744277
http://dx.doi.org/10.32604/or.2023.030611
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