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Progress in research on tumor microenvironment-based spatial omics technologies

Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information. It is characterized by the ability to visualize changes in molecular information and yields intuitive and vivid visual results....

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Detalles Bibliográficos
Autores principales: XIE, FANGMEI, XI, NAITE, HAN, ZEPING, LUO, WENFENG, SHEN, JIAN, LUO, JINGGENG, TANG, XINGKUI, PANG, TING, LV, YUBING, LIANG, JIABING, LIAO, LIYIN, ZHANG, HAOYU, JIANG, YONG, LI, YUGUANG, HE, JINHUA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tech Science Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513957/
https://www.ncbi.nlm.nih.gov/pubmed/37744276
http://dx.doi.org/10.32604/or.2023.029494
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author XIE, FANGMEI
XI, NAITE
HAN, ZEPING
LUO, WENFENG
SHEN, JIAN
LUO, JINGGENG
TANG, XINGKUI
PANG, TING
LV, YUBING
LIANG, JIABING
LIAO, LIYIN
ZHANG, HAOYU
JIANG, YONG
LI, YUGUANG
HE, JINHUA
author_facet XIE, FANGMEI
XI, NAITE
HAN, ZEPING
LUO, WENFENG
SHEN, JIAN
LUO, JINGGENG
TANG, XINGKUI
PANG, TING
LV, YUBING
LIANG, JIABING
LIAO, LIYIN
ZHANG, HAOYU
JIANG, YONG
LI, YUGUANG
HE, JINHUA
author_sort XIE, FANGMEI
collection PubMed
description Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information. It is characterized by the ability to visualize changes in molecular information and yields intuitive and vivid visual results. Spatial omics technologies include spatial transcriptomics, spatial proteomics, spatial metabolomics, and other technologies, the most widely used of which are spatial transcriptomics and spatial proteomics. The tumor microenvironment refers to the surrounding microenvironment in which tumor cells exist, including the surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, various signaling molecules, and extracellular matrix. A key issue in modern tumor biology is the application of spatial omics to the study of the tumor microenvironment, which can reveal problems that conventional research techniques cannot, potentially leading to the development of novel therapeutic agents for cancer. This paper summarizes the progress of research on spatial transcriptomics and spatial proteomics technologies for characterizing the tumor immune microenvironment.
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spelling pubmed-105139572023-09-23 Progress in research on tumor microenvironment-based spatial omics technologies XIE, FANGMEI XI, NAITE HAN, ZEPING LUO, WENFENG SHEN, JIAN LUO, JINGGENG TANG, XINGKUI PANG, TING LV, YUBING LIANG, JIABING LIAO, LIYIN ZHANG, HAOYU JIANG, YONG LI, YUGUANG HE, JINHUA Oncol Res Review Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information. It is characterized by the ability to visualize changes in molecular information and yields intuitive and vivid visual results. Spatial omics technologies include spatial transcriptomics, spatial proteomics, spatial metabolomics, and other technologies, the most widely used of which are spatial transcriptomics and spatial proteomics. The tumor microenvironment refers to the surrounding microenvironment in which tumor cells exist, including the surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, various signaling molecules, and extracellular matrix. A key issue in modern tumor biology is the application of spatial omics to the study of the tumor microenvironment, which can reveal problems that conventional research techniques cannot, potentially leading to the development of novel therapeutic agents for cancer. This paper summarizes the progress of research on spatial transcriptomics and spatial proteomics technologies for characterizing the tumor immune microenvironment. Tech Science Press 2023-09-15 /pmc/articles/PMC10513957/ /pubmed/37744276 http://dx.doi.org/10.32604/or.2023.029494 Text en © 2023 Xie et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
XIE, FANGMEI
XI, NAITE
HAN, ZEPING
LUO, WENFENG
SHEN, JIAN
LUO, JINGGENG
TANG, XINGKUI
PANG, TING
LV, YUBING
LIANG, JIABING
LIAO, LIYIN
ZHANG, HAOYU
JIANG, YONG
LI, YUGUANG
HE, JINHUA
Progress in research on tumor microenvironment-based spatial omics technologies
title Progress in research on tumor microenvironment-based spatial omics technologies
title_full Progress in research on tumor microenvironment-based spatial omics technologies
title_fullStr Progress in research on tumor microenvironment-based spatial omics technologies
title_full_unstemmed Progress in research on tumor microenvironment-based spatial omics technologies
title_short Progress in research on tumor microenvironment-based spatial omics technologies
title_sort progress in research on tumor microenvironment-based spatial omics technologies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513957/
https://www.ncbi.nlm.nih.gov/pubmed/37744276
http://dx.doi.org/10.32604/or.2023.029494
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