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Progress in research on tumor microenvironment-based spatial omics technologies
Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information. It is characterized by the ability to visualize changes in molecular information and yields intuitive and vivid visual results....
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tech Science Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513957/ https://www.ncbi.nlm.nih.gov/pubmed/37744276 http://dx.doi.org/10.32604/or.2023.029494 |
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author | XIE, FANGMEI XI, NAITE HAN, ZEPING LUO, WENFENG SHEN, JIAN LUO, JINGGENG TANG, XINGKUI PANG, TING LV, YUBING LIANG, JIABING LIAO, LIYIN ZHANG, HAOYU JIANG, YONG LI, YUGUANG HE, JINHUA |
author_facet | XIE, FANGMEI XI, NAITE HAN, ZEPING LUO, WENFENG SHEN, JIAN LUO, JINGGENG TANG, XINGKUI PANG, TING LV, YUBING LIANG, JIABING LIAO, LIYIN ZHANG, HAOYU JIANG, YONG LI, YUGUANG HE, JINHUA |
author_sort | XIE, FANGMEI |
collection | PubMed |
description | Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information. It is characterized by the ability to visualize changes in molecular information and yields intuitive and vivid visual results. Spatial omics technologies include spatial transcriptomics, spatial proteomics, spatial metabolomics, and other technologies, the most widely used of which are spatial transcriptomics and spatial proteomics. The tumor microenvironment refers to the surrounding microenvironment in which tumor cells exist, including the surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, various signaling molecules, and extracellular matrix. A key issue in modern tumor biology is the application of spatial omics to the study of the tumor microenvironment, which can reveal problems that conventional research techniques cannot, potentially leading to the development of novel therapeutic agents for cancer. This paper summarizes the progress of research on spatial transcriptomics and spatial proteomics technologies for characterizing the tumor immune microenvironment. |
format | Online Article Text |
id | pubmed-10513957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Tech Science Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-105139572023-09-23 Progress in research on tumor microenvironment-based spatial omics technologies XIE, FANGMEI XI, NAITE HAN, ZEPING LUO, WENFENG SHEN, JIAN LUO, JINGGENG TANG, XINGKUI PANG, TING LV, YUBING LIANG, JIABING LIAO, LIYIN ZHANG, HAOYU JIANG, YONG LI, YUGUANG HE, JINHUA Oncol Res Review Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information. It is characterized by the ability to visualize changes in molecular information and yields intuitive and vivid visual results. Spatial omics technologies include spatial transcriptomics, spatial proteomics, spatial metabolomics, and other technologies, the most widely used of which are spatial transcriptomics and spatial proteomics. The tumor microenvironment refers to the surrounding microenvironment in which tumor cells exist, including the surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, various signaling molecules, and extracellular matrix. A key issue in modern tumor biology is the application of spatial omics to the study of the tumor microenvironment, which can reveal problems that conventional research techniques cannot, potentially leading to the development of novel therapeutic agents for cancer. This paper summarizes the progress of research on spatial transcriptomics and spatial proteomics technologies for characterizing the tumor immune microenvironment. Tech Science Press 2023-09-15 /pmc/articles/PMC10513957/ /pubmed/37744276 http://dx.doi.org/10.32604/or.2023.029494 Text en © 2023 Xie et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review XIE, FANGMEI XI, NAITE HAN, ZEPING LUO, WENFENG SHEN, JIAN LUO, JINGGENG TANG, XINGKUI PANG, TING LV, YUBING LIANG, JIABING LIAO, LIYIN ZHANG, HAOYU JIANG, YONG LI, YUGUANG HE, JINHUA Progress in research on tumor microenvironment-based spatial omics technologies |
title | Progress in research on tumor microenvironment-based spatial omics technologies |
title_full | Progress in research on tumor microenvironment-based spatial omics technologies |
title_fullStr | Progress in research on tumor microenvironment-based spatial omics technologies |
title_full_unstemmed | Progress in research on tumor microenvironment-based spatial omics technologies |
title_short | Progress in research on tumor microenvironment-based spatial omics technologies |
title_sort | progress in research on tumor microenvironment-based spatial omics technologies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513957/ https://www.ncbi.nlm.nih.gov/pubmed/37744276 http://dx.doi.org/10.32604/or.2023.029494 |
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