A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

Pancreatic cancer is one of the deadliest diseases in human malignancies. Among total pancreatic cancer patients, ~10% of patients are categorized as familial pancreatic cancer (FPC) patients, carrying germline mutations of the genes involved in DNA repair pathways (e.g., BRCA2). Personalized medici...

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Detalles Bibliográficos
Autores principales: Lee, EunJung, Archasappawat, Suyakarn, Ji, Keely, Pena, Jocelyn, Fernandez-Vega, Virneliz, Gangaraju, Ritika, Beesabathuni, Nitin Sai, Kim, Martin Jean, Tian, Qi, Shah, Priya S., Scampavia, Louis, Spicer, Timothy P., Hwang, Chang-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514057/
https://www.ncbi.nlm.nih.gov/pubmed/37735513
http://dx.doi.org/10.1038/s41419-023-06145-9

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