Structure guided mimicry of an essential P. falciparum receptor-ligand complex enhances cross neutralizing antibodies

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Invasion of human erythrocytes by Plasmodium falciparum (Pf) merozoites relies on the interaction between two parasite proteins: apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2). While antibodies to AMA1 provide limited protection against Pf in non-human primate malaria models, cli...

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Detalles Bibliográficos
Autores principales: Yanik, Sean, Venkatesh, Varsha, Parker, Michelle L., Ramaswamy, Raghavendran, Diouf, Ababacar, Sarkar, Deepti, Miura, Kazutoyo, Long, Carole A., Boulanger, Martin J., Srinivasan, Prakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514071/
https://www.ncbi.nlm.nih.gov/pubmed/37735574
http://dx.doi.org/10.1038/s41467-023-41636-5
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