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Engineering RsDddA as mitochondrial base editor with wide target compatibility and enhanced activity

Double-stranded DNA-specific cytidine deaminase (DddA) base editors hold great promise for applications in bio-medical research, medicine, and biotechnology. Strict sequence preference on spacing region presents a challenge for DddA editors to reach their full potential. To overcome this sequence-co...

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Detalles Bibliográficos
Autores principales:	Cheng, Kai, Li, Cao, Jin, Jiachuan, Qian, Xuezhen, Guo, Jiayin, Shen, Limini, Dai, YiChen, Zhang, Xue, Li, Zhanwei, Guan, Yichun, Zhou, Fei, Tang, Jin, Zhang, Jun, Shen, Bin, Lou, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514076/ https://www.ncbi.nlm.nih.gov/pubmed/37744175 http://dx.doi.org/10.1016/j.omtn.2023.09.005

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