Sézary syndrome originates from heavily mutated hematopoietic progenitors

The pathogenesis of cutaneous T-cell lymphoma (CTCL) remains unclear. Using single-cell RNA or T-cell receptor (TCR) sequencing of 32 619 CD3(+)CD4(+) and CD26(+)/CD7(+) and 29 932 CD3(+)CD4(+) and CD26(−)/CD7(−) lymphocytes from the peripheral blood of 7 patients with CTCL, coupled to single-cell A...

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Detalles Bibliográficos
Autores principales: Harro, Carly M., Sprenger, Kimberly B., Chaurio, Ricardo A., Powers, John J., Innamarato, Patrick, Anadon, Carmen M., Zhang, Yumeng, Biswas, Subir, Mandal, Gunjan, Mine, Jessica A., Cortina, Carla, Nagy, Mate Z., Martin, Alexandra L., Handley, Katelyn F., Borjas, Gustavo J., Chen, Pei-Ling, Pinilla-Ibarz, Javier, Sokol, Lubomir, Yu, Xiaoqing, Conejo-Garcia, Jose R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514084/
https://www.ncbi.nlm.nih.gov/pubmed/37531660
http://dx.doi.org/10.1182/bloodadvances.2022008562

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