Impact of Bariatric Surgery in the Short and Long Term: A Need for Time-Dependent Dosing of Drugs

Sparse information is available on pharmacokinetic changes of drugs over time after bariatric surgery. By reviewing the literature on the short- and long-term pharmacokinetic changes of drugs, several patterns were identified for 39 drugs. No relevant pharmacokinetic changes were identified for roug...

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Autores principales: Lau, Cedric, van Kesteren, Charlotte, Smeenk, Robert, Huitema, Alwin, Knibbe, Catherijne A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514130/
https://www.ncbi.nlm.nih.gov/pubmed/37594672
http://dx.doi.org/10.1007/s11695-023-06770-5
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author Lau, Cedric
van Kesteren, Charlotte
Smeenk, Robert
Huitema, Alwin
Knibbe, Catherijne A. J.
author_facet Lau, Cedric
van Kesteren, Charlotte
Smeenk, Robert
Huitema, Alwin
Knibbe, Catherijne A. J.
author_sort Lau, Cedric
collection PubMed
description Sparse information is available on pharmacokinetic changes of drugs over time after bariatric surgery. By reviewing the literature on the short- and long-term pharmacokinetic changes of drugs, several patterns were identified for 39 drugs. No relevant pharmacokinetic changes were identified for roughly a third of the drugs. Of the remaining drugs, levels were variable and partly unpredictable shortly after the surgery. In the long term, most of the drug levels remain altered, but in some cases they returned to preoperative values. Based on the changes and the efficacy-safety balance of each drug, clinicians may need to perform additional clinical monitoring for specific drugs, including measuring drug levels. This review provides suggestions for clinicians and pharmacists for specific time-dependent drug dosing advice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11695-023-06770-5.
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spelling pubmed-105141302023-09-23 Impact of Bariatric Surgery in the Short and Long Term: A Need for Time-Dependent Dosing of Drugs Lau, Cedric van Kesteren, Charlotte Smeenk, Robert Huitema, Alwin Knibbe, Catherijne A. J. Obes Surg Review Sparse information is available on pharmacokinetic changes of drugs over time after bariatric surgery. By reviewing the literature on the short- and long-term pharmacokinetic changes of drugs, several patterns were identified for 39 drugs. No relevant pharmacokinetic changes were identified for roughly a third of the drugs. Of the remaining drugs, levels were variable and partly unpredictable shortly after the surgery. In the long term, most of the drug levels remain altered, but in some cases they returned to preoperative values. Based on the changes and the efficacy-safety balance of each drug, clinicians may need to perform additional clinical monitoring for specific drugs, including measuring drug levels. This review provides suggestions for clinicians and pharmacists for specific time-dependent drug dosing advice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11695-023-06770-5. Springer US 2023-08-18 2023 /pmc/articles/PMC10514130/ /pubmed/37594672 http://dx.doi.org/10.1007/s11695-023-06770-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Lau, Cedric
van Kesteren, Charlotte
Smeenk, Robert
Huitema, Alwin
Knibbe, Catherijne A. J.
Impact of Bariatric Surgery in the Short and Long Term: A Need for Time-Dependent Dosing of Drugs
title Impact of Bariatric Surgery in the Short and Long Term: A Need for Time-Dependent Dosing of Drugs
title_full Impact of Bariatric Surgery in the Short and Long Term: A Need for Time-Dependent Dosing of Drugs
title_fullStr Impact of Bariatric Surgery in the Short and Long Term: A Need for Time-Dependent Dosing of Drugs
title_full_unstemmed Impact of Bariatric Surgery in the Short and Long Term: A Need for Time-Dependent Dosing of Drugs
title_short Impact of Bariatric Surgery in the Short and Long Term: A Need for Time-Dependent Dosing of Drugs
title_sort impact of bariatric surgery in the short and long term: a need for time-dependent dosing of drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514130/
https://www.ncbi.nlm.nih.gov/pubmed/37594672
http://dx.doi.org/10.1007/s11695-023-06770-5
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