Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING

Oncogenes destabilize STING in epithelial cell-derived cancer cells, such as head and neck squamous cell carcinomas (HNSCCs), to promote immune escape. Despite the abundance of tumor-infiltrating myeloid cells, HNSCC presents notable resistance to STING stimulation. Here, we show how saturated fatty...

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Detalles Bibliográficos
Autores principales: Heath, Blake R., Gong, Wang, Taner, Hülya F., Broses, Luke, Okuyama, Kohei, Cheng, Wanqing, Jin, Max, Fitzsimonds, Zackary R., Manousidaki, Andriana, Wu, Yuesong, Zhang, Shaoping, Wen, Haitao, Chinn, Steven B., Bartee, Eric, Xie, Yuying, Moon, James J., Lei, Yu Leo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514241/
https://www.ncbi.nlm.nih.gov/pubmed/36952341
http://dx.doi.org/10.1016/j.celrep.2023.112303

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