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A cross-sectional case–control study on the structural connectome in recovered hospitalized COVID-19 patients
COVID-19 can induce neurological sequelae, negatively affecting the quality of life. Unravelling this illness's impact on structural brain connectivity, white-matter microstructure (WMM), and cognitive performance may help elucidate its implications. This cross-sectional study aimed to investig...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514277/ https://www.ncbi.nlm.nih.gov/pubmed/37735584 http://dx.doi.org/10.1038/s41598-023-42429-y |
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author | Lathouwers, Elke Radwan, Ahmed Blommaert, Jeroen Stas, Lara Tassignon, Bruno Allard, Sabine D. De Ridder, Filip De Waele, Elisabeth Hoornaert, Nicole Lacor, Patrick Mertens, Rembert Naeyaert, Maarten Raeymaekers, Hubert Seyler, Lucie Vanbinst, Anne-Marie Van Liedekerke, Lien Van Schependom, Jeroen Van Schuerbeek, Peter Provyn, Steven Roelands, Bart Vandekerckhove, Marie Meeusen, Romain Sunaert, Stefan Nagels, Guy De Mey, Johan De Pauw, Kevin |
author_facet | Lathouwers, Elke Radwan, Ahmed Blommaert, Jeroen Stas, Lara Tassignon, Bruno Allard, Sabine D. De Ridder, Filip De Waele, Elisabeth Hoornaert, Nicole Lacor, Patrick Mertens, Rembert Naeyaert, Maarten Raeymaekers, Hubert Seyler, Lucie Vanbinst, Anne-Marie Van Liedekerke, Lien Van Schependom, Jeroen Van Schuerbeek, Peter Provyn, Steven Roelands, Bart Vandekerckhove, Marie Meeusen, Romain Sunaert, Stefan Nagels, Guy De Mey, Johan De Pauw, Kevin |
author_sort | Lathouwers, Elke |
collection | PubMed |
description | COVID-19 can induce neurological sequelae, negatively affecting the quality of life. Unravelling this illness's impact on structural brain connectivity, white-matter microstructure (WMM), and cognitive performance may help elucidate its implications. This cross-sectional study aimed to investigate differences in these factors between former hospitalised COVID-19 patients (COV) and healthy controls. Group differences in structural brain connectivity were explored using Welch-two sample t-tests and two-sample Mann–Whitney U tests. Multivariate linear models were constructed (one per region) to examine fixel-based group differences. Differences in cognitive performance between groups were investigated using Wilcoxon Rank Sum tests. Possible effects of bundle-specific FD measures on cognitive performance were explored using a two-group path model. No differences in whole-brain structural organisation were found. Bundle-specific metrics showed reduced fiber density (p = 0.012, Hedges’ g = 0.884) and fiber density cross-section (p = 0.007, Hedges’ g = 0.945) in the motor segment of the corpus callosum in COV compared to healthy controls. Cognitive performance on the motor praxis and digit symbol substitution tests was worse in COV than healthy controls (p < 0.001, r = 0.688; p = 0.013, r = 422, respectively). Associations between the cognitive performance and bundle-specific FD measures differed significantly between groups. WMM and cognitive performance differences were observed between COV and healthy controls. |
format | Online Article Text |
id | pubmed-10514277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105142772023-09-23 A cross-sectional case–control study on the structural connectome in recovered hospitalized COVID-19 patients Lathouwers, Elke Radwan, Ahmed Blommaert, Jeroen Stas, Lara Tassignon, Bruno Allard, Sabine D. De Ridder, Filip De Waele, Elisabeth Hoornaert, Nicole Lacor, Patrick Mertens, Rembert Naeyaert, Maarten Raeymaekers, Hubert Seyler, Lucie Vanbinst, Anne-Marie Van Liedekerke, Lien Van Schependom, Jeroen Van Schuerbeek, Peter Provyn, Steven Roelands, Bart Vandekerckhove, Marie Meeusen, Romain Sunaert, Stefan Nagels, Guy De Mey, Johan De Pauw, Kevin Sci Rep Article COVID-19 can induce neurological sequelae, negatively affecting the quality of life. Unravelling this illness's impact on structural brain connectivity, white-matter microstructure (WMM), and cognitive performance may help elucidate its implications. This cross-sectional study aimed to investigate differences in these factors between former hospitalised COVID-19 patients (COV) and healthy controls. Group differences in structural brain connectivity were explored using Welch-two sample t-tests and two-sample Mann–Whitney U tests. Multivariate linear models were constructed (one per region) to examine fixel-based group differences. Differences in cognitive performance between groups were investigated using Wilcoxon Rank Sum tests. Possible effects of bundle-specific FD measures on cognitive performance were explored using a two-group path model. No differences in whole-brain structural organisation were found. Bundle-specific metrics showed reduced fiber density (p = 0.012, Hedges’ g = 0.884) and fiber density cross-section (p = 0.007, Hedges’ g = 0.945) in the motor segment of the corpus callosum in COV compared to healthy controls. Cognitive performance on the motor praxis and digit symbol substitution tests was worse in COV than healthy controls (p < 0.001, r = 0.688; p = 0.013, r = 422, respectively). Associations between the cognitive performance and bundle-specific FD measures differed significantly between groups. WMM and cognitive performance differences were observed between COV and healthy controls. Nature Publishing Group UK 2023-09-21 /pmc/articles/PMC10514277/ /pubmed/37735584 http://dx.doi.org/10.1038/s41598-023-42429-y Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lathouwers, Elke Radwan, Ahmed Blommaert, Jeroen Stas, Lara Tassignon, Bruno Allard, Sabine D. De Ridder, Filip De Waele, Elisabeth Hoornaert, Nicole Lacor, Patrick Mertens, Rembert Naeyaert, Maarten Raeymaekers, Hubert Seyler, Lucie Vanbinst, Anne-Marie Van Liedekerke, Lien Van Schependom, Jeroen Van Schuerbeek, Peter Provyn, Steven Roelands, Bart Vandekerckhove, Marie Meeusen, Romain Sunaert, Stefan Nagels, Guy De Mey, Johan De Pauw, Kevin A cross-sectional case–control study on the structural connectome in recovered hospitalized COVID-19 patients |
title | A cross-sectional case–control study on the structural connectome in recovered hospitalized COVID-19 patients |
title_full | A cross-sectional case–control study on the structural connectome in recovered hospitalized COVID-19 patients |
title_fullStr | A cross-sectional case–control study on the structural connectome in recovered hospitalized COVID-19 patients |
title_full_unstemmed | A cross-sectional case–control study on the structural connectome in recovered hospitalized COVID-19 patients |
title_short | A cross-sectional case–control study on the structural connectome in recovered hospitalized COVID-19 patients |
title_sort | cross-sectional case–control study on the structural connectome in recovered hospitalized covid-19 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514277/ https://www.ncbi.nlm.nih.gov/pubmed/37735584 http://dx.doi.org/10.1038/s41598-023-42429-y |
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