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A novel monoclonal antibody against 6-sulfo sialyl Lewis x glycans attenuates murine allergic rhinitis by suppressing Th2 immune responses

Lymphocyte homing is mediated by the interaction between L-selectin on lymphocytes and its glycoprotein ligands modified with 6-sulfo sialyl Lewis x (6-sulfo sLe(x)) glycans on high endothelial venules (HEVs) in peripheral lymph nodes (PLNs). However, the lack of specific antibodies reactive with bo...

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Detalles Bibliográficos
Autores principales: Liu, Wei, Xiong, Wei, Liu, Wenxin, Hirakawa, Jotaro, Kawashima, Hiroto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514285/
https://www.ncbi.nlm.nih.gov/pubmed/37735247
http://dx.doi.org/10.1038/s41598-023-43017-w