The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury

The enzyme arginase 1 (A1) hydrolyzes the amino acid arginine to form L-ornithine and urea. Ornithine is further converted to polyamines by the ornithine decarboxylase (ODC) enzyme. We previously reported that deletion of myeloid A1 in mice exacerbates retinal damage after ischemia/reperfusion (IR)...

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Detalles Bibliográficos
Autores principales: Shosha, Esraa, Shahror, Rami A., Morris, Carol A., Xu, Zhimin, Lucas, Rudolf, McGee-Lawrence, Meghan E., Rusch, Nancy J., Caldwell, Ruth B., Fouda, Abdelrahman Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514323/
https://www.ncbi.nlm.nih.gov/pubmed/37735154
http://dx.doi.org/10.1038/s41419-023-06147-7

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