SRC and TKS5 mediated podosome formation in fibroblasts promotes extracellular matrix invasion and pulmonary fibrosis

The activation and accumulation of lung fibroblasts resulting in aberrant deposition of extracellular matrix components, is a pathogenic hallmark of Idiopathic Pulmonary Fibrosis, a lethal and incurable disease. In this report, increased expression of TKS5, a scaffold protein essential for the forma...

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Detalles Bibliográficos
Autores principales: Barbayianni, Ilianna, Kanellopoulou, Paraskevi, Fanidis, Dionysios, Nastos, Dimitris, Ntouskou, Eleftheria-Dimitra, Galaris, Apostolos, Harokopos, Vaggelis, Hatzis, Pantelis, Tsitoura, Eliza, Homer, Robert, Kaminski, Naftali, Antoniou, Katerina M., Crestani, Bruno, Tzouvelekis, Argyrios, Aidinis, Vassilis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514346/
https://www.ncbi.nlm.nih.gov/pubmed/37735172
http://dx.doi.org/10.1038/s41467-023-41614-x

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