Cargando…

A protective maternal nutrient concomitant intake associated with acute leukemia might be modified by sex, in children under 2 years

INTRODUCTION: Maternal dietary consumption during pregnancy has been inconclusively associated with acute leukemia (AL) in infants, probably because epidemiological evidence has emerged mainly from the analysis of one-by-one nutrient, which is not a real-life scenario. Our objective was to evaluate...

Descripción completa

Detalles Bibliográficos
Autores principales: Mérida-Ortega, Ángel, Pérez-Saldivar, María Luisa, Espinoza-Hernández, Laura E., Dorantes-Acosta, Elisa M., Torres-Nava, José Refugio, Solís-Labastida, Karina A., Paredes-Aguilera, Rogelio, Velázquez-Aviña, Martha M., Espinosa-Elizondo, Rosa Martha, Miranda-Madrazo, M. Raquel, González-Ávila, Ana Itamar, Rodríguez-Villalobos, Luis Rodolfo, Dosta-Herrera, Juan José, Mondragón-García, Javier A., Castañeda-Echevarría, Alejandro, López-Caballero, M. Guadalupe, Martínez-Silva, Sofía I., Rivera-González, Juan, Hernández-Pineda, Norma Angélica, Flores-Botello, Jesús, Pérez-Gómez, Jessica Arleet, Rodríguez-Vázquez, María Adriana, Torres-Valle, Delfino, Olvera-Durán, Jaime Ángel, Martínez-Ríos, Annel, García‐Cortés, Luis R., Almeida-Hernández, Carolina, Flores-Lujano, Janet, Núñez-Enríquez, Juan Carlos, Mata-Rocha, Minerva, Rosas-Vargas, Haydeé, Duarte-Rodríguez, David Aldebarán, Jiménez-Morales, Silvia, Mejía-Arangure, Juan Manuel, López-Carrillo, Lizbeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514356/
https://www.ncbi.nlm.nih.gov/pubmed/37746300
http://dx.doi.org/10.3389/fonc.2023.1239147
_version_ 1785108709137973248
author Mérida-Ortega, Ángel
Pérez-Saldivar, María Luisa
Espinoza-Hernández, Laura E.
Dorantes-Acosta, Elisa M.
Torres-Nava, José Refugio
Solís-Labastida, Karina A.
Paredes-Aguilera, Rogelio
Velázquez-Aviña, Martha M.
Espinosa-Elizondo, Rosa Martha
Miranda-Madrazo, M. Raquel
González-Ávila, Ana Itamar
Rodríguez-Villalobos, Luis Rodolfo
Dosta-Herrera, Juan José
Mondragón-García, Javier A.
Castañeda-Echevarría, Alejandro
López-Caballero, M. Guadalupe
Martínez-Silva, Sofía I.
Rivera-González, Juan
Hernández-Pineda, Norma Angélica
Flores-Botello, Jesús
Pérez-Gómez, Jessica Arleet
Rodríguez-Vázquez, María Adriana
Torres-Valle, Delfino
Olvera-Durán, Jaime Ángel
Martínez-Ríos, Annel
García‐Cortés, Luis R.
Almeida-Hernández, Carolina
Flores-Lujano, Janet
Núñez-Enríquez, Juan Carlos
Mata-Rocha, Minerva
Rosas-Vargas, Haydeé
Duarte-Rodríguez, David Aldebarán
Jiménez-Morales, Silvia
Mejía-Arangure, Juan Manuel
López-Carrillo, Lizbeth
author_facet Mérida-Ortega, Ángel
Pérez-Saldivar, María Luisa
Espinoza-Hernández, Laura E.
Dorantes-Acosta, Elisa M.
Torres-Nava, José Refugio
Solís-Labastida, Karina A.
Paredes-Aguilera, Rogelio
Velázquez-Aviña, Martha M.
Espinosa-Elizondo, Rosa Martha
Miranda-Madrazo, M. Raquel
González-Ávila, Ana Itamar
Rodríguez-Villalobos, Luis Rodolfo
Dosta-Herrera, Juan José
Mondragón-García, Javier A.
Castañeda-Echevarría, Alejandro
López-Caballero, M. Guadalupe
Martínez-Silva, Sofía I.
Rivera-González, Juan
Hernández-Pineda, Norma Angélica
Flores-Botello, Jesús
Pérez-Gómez, Jessica Arleet
Rodríguez-Vázquez, María Adriana
Torres-Valle, Delfino
Olvera-Durán, Jaime Ángel
Martínez-Ríos, Annel
García‐Cortés, Luis R.
Almeida-Hernández, Carolina
Flores-Lujano, Janet
Núñez-Enríquez, Juan Carlos
Mata-Rocha, Minerva
Rosas-Vargas, Haydeé
Duarte-Rodríguez, David Aldebarán
Jiménez-Morales, Silvia
Mejía-Arangure, Juan Manuel
López-Carrillo, Lizbeth
author_sort Mérida-Ortega, Ángel
collection PubMed
description INTRODUCTION: Maternal dietary consumption during pregnancy has been inconclusively associated with acute leukemia (AL) in infants, probably because epidemiological evidence has emerged mainly from the analysis of one-by-one nutrient, which is not a real-life scenario. Our objective was to evaluate the association between AL in Mexican children under 2 years of age and their mothers’ nutrients concomitant intake during pregnancy, as well as to explore whether there are differences between girls and boys. METHODS: We conducted a study of 110 cases of AL and 252 hospital-based controls in the Mexico City Metropolitan area from 2010 to 2019. We obtained information on maternal intake of 32 nutrients by a food frequency questionnaire and used weighted quantile sum regression to identify nutrient concomitant intakes. RESULTS: We found a concomitant intake of nutrients negatively associated with AL (OR 0.17; CI95% 0.03,0.88) only among girls; and we did not find a nutrient concomitant intake positively associated with AL. DISCUSSION: This is the first study that suggests nutrients that have been individually associated with AL are not necessarily the same in the presence of other nutrients (concomitant intake); as well as that maternal diet might reduce AL risk only in girls.
format Online
Article
Text
id pubmed-10514356
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-105143562023-09-23 A protective maternal nutrient concomitant intake associated with acute leukemia might be modified by sex, in children under 2 years Mérida-Ortega, Ángel Pérez-Saldivar, María Luisa Espinoza-Hernández, Laura E. Dorantes-Acosta, Elisa M. Torres-Nava, José Refugio Solís-Labastida, Karina A. Paredes-Aguilera, Rogelio Velázquez-Aviña, Martha M. Espinosa-Elizondo, Rosa Martha Miranda-Madrazo, M. Raquel González-Ávila, Ana Itamar Rodríguez-Villalobos, Luis Rodolfo Dosta-Herrera, Juan José Mondragón-García, Javier A. Castañeda-Echevarría, Alejandro López-Caballero, M. Guadalupe Martínez-Silva, Sofía I. Rivera-González, Juan Hernández-Pineda, Norma Angélica Flores-Botello, Jesús Pérez-Gómez, Jessica Arleet Rodríguez-Vázquez, María Adriana Torres-Valle, Delfino Olvera-Durán, Jaime Ángel Martínez-Ríos, Annel García‐Cortés, Luis R. Almeida-Hernández, Carolina Flores-Lujano, Janet Núñez-Enríquez, Juan Carlos Mata-Rocha, Minerva Rosas-Vargas, Haydeé Duarte-Rodríguez, David Aldebarán Jiménez-Morales, Silvia Mejía-Arangure, Juan Manuel López-Carrillo, Lizbeth Front Oncol Oncology INTRODUCTION: Maternal dietary consumption during pregnancy has been inconclusively associated with acute leukemia (AL) in infants, probably because epidemiological evidence has emerged mainly from the analysis of one-by-one nutrient, which is not a real-life scenario. Our objective was to evaluate the association between AL in Mexican children under 2 years of age and their mothers’ nutrients concomitant intake during pregnancy, as well as to explore whether there are differences between girls and boys. METHODS: We conducted a study of 110 cases of AL and 252 hospital-based controls in the Mexico City Metropolitan area from 2010 to 2019. We obtained information on maternal intake of 32 nutrients by a food frequency questionnaire and used weighted quantile sum regression to identify nutrient concomitant intakes. RESULTS: We found a concomitant intake of nutrients negatively associated with AL (OR 0.17; CI95% 0.03,0.88) only among girls; and we did not find a nutrient concomitant intake positively associated with AL. DISCUSSION: This is the first study that suggests nutrients that have been individually associated with AL are not necessarily the same in the presence of other nutrients (concomitant intake); as well as that maternal diet might reduce AL risk only in girls. Frontiers Media S.A. 2023-09-07 /pmc/articles/PMC10514356/ /pubmed/37746300 http://dx.doi.org/10.3389/fonc.2023.1239147 Text en Copyright © 2023 Mérida-Ortega, Pérez-Saldivar, Espinoza-Hernández, Dorantes-Acosta, Torres-Nava, Solís-Labastida, Paredes-Aguilera, Velázquez-Aviña, Espinosa-Elizondo, Miranda-Madrazo, González-Ávila, Rodríguez-Villalobos, Dosta-Herrera, Mondragón-García, Castañeda-Echevarría, López-Caballero, Martínez-Silva, Rivera-González, Hernández-Pineda, Flores-Botello, Pérez-Gómez, Rodríguez-Vázquez, Torres-Valle, Olvera-Durán, Martínez-Ríos, García‐Cortés, Almeida-Hernández, Flores-Lujano, Núñez-Enríquez, Mata-Rocha, Rosas-Vargas, Duarte-Rodríguez, Jiménez-Morales, Mejía-Arangure and López-Carrillo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Mérida-Ortega, Ángel
Pérez-Saldivar, María Luisa
Espinoza-Hernández, Laura E.
Dorantes-Acosta, Elisa M.
Torres-Nava, José Refugio
Solís-Labastida, Karina A.
Paredes-Aguilera, Rogelio
Velázquez-Aviña, Martha M.
Espinosa-Elizondo, Rosa Martha
Miranda-Madrazo, M. Raquel
González-Ávila, Ana Itamar
Rodríguez-Villalobos, Luis Rodolfo
Dosta-Herrera, Juan José
Mondragón-García, Javier A.
Castañeda-Echevarría, Alejandro
López-Caballero, M. Guadalupe
Martínez-Silva, Sofía I.
Rivera-González, Juan
Hernández-Pineda, Norma Angélica
Flores-Botello, Jesús
Pérez-Gómez, Jessica Arleet
Rodríguez-Vázquez, María Adriana
Torres-Valle, Delfino
Olvera-Durán, Jaime Ángel
Martínez-Ríos, Annel
García‐Cortés, Luis R.
Almeida-Hernández, Carolina
Flores-Lujano, Janet
Núñez-Enríquez, Juan Carlos
Mata-Rocha, Minerva
Rosas-Vargas, Haydeé
Duarte-Rodríguez, David Aldebarán
Jiménez-Morales, Silvia
Mejía-Arangure, Juan Manuel
López-Carrillo, Lizbeth
A protective maternal nutrient concomitant intake associated with acute leukemia might be modified by sex, in children under 2 years
title A protective maternal nutrient concomitant intake associated with acute leukemia might be modified by sex, in children under 2 years
title_full A protective maternal nutrient concomitant intake associated with acute leukemia might be modified by sex, in children under 2 years
title_fullStr A protective maternal nutrient concomitant intake associated with acute leukemia might be modified by sex, in children under 2 years
title_full_unstemmed A protective maternal nutrient concomitant intake associated with acute leukemia might be modified by sex, in children under 2 years
title_short A protective maternal nutrient concomitant intake associated with acute leukemia might be modified by sex, in children under 2 years
title_sort protective maternal nutrient concomitant intake associated with acute leukemia might be modified by sex, in children under 2 years
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514356/
https://www.ncbi.nlm.nih.gov/pubmed/37746300
http://dx.doi.org/10.3389/fonc.2023.1239147
work_keys_str_mv AT meridaortegaangel aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT perezsaldivarmarialuisa aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT espinozahernandezlaurae aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT dorantesacostaelisam aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT torresnavajoserefugio aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT solislabastidakarinaa aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT paredesaguilerarogelio aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT velazquezavinamartham aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT espinosaelizondorosamartha aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT mirandamadrazomraquel aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT gonzalezavilaanaitamar aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT rodriguezvillalobosluisrodolfo aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT dostaherrerajuanjose aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT mondragongarciajaviera aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT castanedaechevarriaalejandro aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT lopezcaballeromguadalupe aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT martinezsilvasofiai aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT riveragonzalezjuan aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT hernandezpinedanormaangelica aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT floresbotellojesus aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT perezgomezjessicaarleet aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT rodriguezvazquezmariaadriana aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT torresvalledelfino aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT olveraduranjaimeangel aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT martinezriosannel aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT garciacortesluisr aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT almeidahernandezcarolina aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT floreslujanojanet aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT nunezenriquezjuancarlos aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT matarochaminerva aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT rosasvargashaydee aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT duarterodriguezdavidaldebaran aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT jimenezmoralessilvia aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT mejiaarangurejuanmanuel aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT lopezcarrillolizbeth aprotectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT meridaortegaangel protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT perezsaldivarmarialuisa protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT espinozahernandezlaurae protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT dorantesacostaelisam protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT torresnavajoserefugio protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT solislabastidakarinaa protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT paredesaguilerarogelio protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT velazquezavinamartham protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT espinosaelizondorosamartha protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT mirandamadrazomraquel protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT gonzalezavilaanaitamar protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT rodriguezvillalobosluisrodolfo protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT dostaherrerajuanjose protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT mondragongarciajaviera protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT castanedaechevarriaalejandro protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT lopezcaballeromguadalupe protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT martinezsilvasofiai protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT riveragonzalezjuan protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT hernandezpinedanormaangelica protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT floresbotellojesus protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT perezgomezjessicaarleet protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT rodriguezvazquezmariaadriana protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT torresvalledelfino protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT olveraduranjaimeangel protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT martinezriosannel protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT garciacortesluisr protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT almeidahernandezcarolina protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT floreslujanojanet protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT nunezenriquezjuancarlos protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT matarochaminerva protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT rosasvargashaydee protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT duarterodriguezdavidaldebaran protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT jimenezmoralessilvia protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT mejiaarangurejuanmanuel protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years
AT lopezcarrillolizbeth protectivematernalnutrientconcomitantintakeassociatedwithacuteleukemiamightbemodifiedbysexinchildrenunder2years