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Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation
BACKGROUND: Patients established on thiopurines (e.g., azathioprine) are recommended to undergo three-monthly blood tests for the early detection of blood, liver, or kidney toxicity. These side-effects are uncommon during long-term treatment. We developed a prognostic model that could be used to inf...
Autores principales: | Nakafero, Georgina, Card, Tim, Grainge, Matthew J., Williams, Hywel C., Taal, Maarten W., Aithal, Guruprasad P., Fox, Christopher P., Mallen, Christian D., van der Windt, Danielle A., Stevenson, Matthew D., Riley, Richard D., Abhishek, Abhishek |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514402/ https://www.ncbi.nlm.nih.gov/pubmed/37745026 http://dx.doi.org/10.1016/j.eclinm.2023.102213 |
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