Cargando…

Efficacy of metformin targets on cardiometabolic health in the general population and non-diabetic individuals: a Mendelian randomization study

BACKGROUND: Metformin shows beneficial effects on cardiometabolic health in diabetic individuals. However, the beneficial effects in the general population, especially in non-diabetic individuals are unclear. We aim to estimate the effects of perturbation of seven metformin targets on cardiometaboli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Jie, Xu, Min, Yang, Qian, Hu, Chunyan, Walker, Venexia, Lu, Jieli, Wang, Jiqiu, Liu, Ruixin, Xu, Yu, Wang, Tiange, Zhao, Zhiyun, Yuan, Jinqiu, Burgess, Stephen, Au Yeung, Shiu Lun, Luo, Shan, Anderson, Emma L., Holmes, Michael V., Smith, George Davey, Ning, Guang, Wang, Weiqing, Gaunt, Tom R., Bi, Yufang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514430/ https://www.ncbi.nlm.nih.gov/pubmed/37734206 http://dx.doi.org/10.1016/j.ebiom.2023.104803

Ejemplares similares

Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer’s disease risk in the general population: a Mendelian randomisation study
por: Zheng, Jie, et al.
Publicado: (2022)

SGLT2 Inhibition, Choline Metabolites, and Cardiometabolic Diseases: A Mediation Mendelian Randomization Study
por: Xu, Min, et al.
Publicado: (2022)

Independent Associations of Education, Intelligence, and Cognition With Hypertension and the Mediating Effects of Cardiometabolic Risk Factors: A Mendelian Randomization Study
por: Wang, Yiying, et al.
Publicado: (2022)

Causal associations of sarcopenia‐related traits with cardiometabolic disease and Alzheimer's disease and the mediating role of insulin resistance: A Mendelian randomization study
por: Ye, Chaojie, et al.
Publicado: (2023)

Causal Association Between Obesity, Circulating Glutamine Levels, and Depression: A Mendelian Randomization Study
por: He, Ruixin, et al.
Publicado: (2022)

Dissecting Causal Relationships Between Gut Microbiota, Blood Metabolites, and Stroke: A Mendelian Randomization Study
por: Wang, Qi, et al.
Publicado: (2023)

Mendelian Randomization Analysis Support Causal Associations of HbA1c with Circulating Triglyceride, Total and Low-density Lipoprotein Cholesterol in a Chinese Population
por: Jia, Xu, et al.
Publicado: (2019)

Impact of glycemic traits, type 2 diabetes and metformin use on breast and prostate cancer risk: a Mendelian randomization study
por: Au Yeung, Shiu Lun, et al.
Publicado: (2019)

Associations of body shapes with insulin resistance and cardiometabolic risk in middle-aged and elderly Chinese
por: Zhou, Yulin, et al.
Publicado: (2021)

Association between mid-upper arm circumference and cardiometabolic risk in Chinese population: a cross-sectional study
por: Hou, Yanan, et al.
Publicado: (2019)

Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bowel Disease via Circulating Metabolites: A Mediation Mendelian Randomization Study
por: Jia, Xiaojing, et al.
Publicado: (2023)

Standardizing the reporting of Mendelian randomization studies
por: Au Yeung, Shiu Lun, et al.
Publicado: (2023)

Mendelian randomization applied to pharmaceutical use: the case of metformin and lung cancer
por: Yarmolinsky, James, et al.
Publicado: (2020)

Causal Effect of Relative Carbohydrate Intake on Hypertension through Psychological Well-Being and Adiposity: A Mendelian Randomization Study
por: Ye, Chaojie, et al.
Publicado: (2023)

Sexual Dimorphism in the Association of Serum Retinol-Binding Protein-4 With Long-Term Dynamic Metabolic Profiles in Non-Diabetes
por: Xiang, Jiali, et al.
Publicado: (2022)

Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization
por: Hou, Tianzhichao, et al.
Publicado: (2023)

Evaluating the distinct pleiotropic effects of omega-3 fatty acids on type 2 diabetes mellitus: a mendelian randomization study
por: Hu, Chunyan, et al.
Publicado: (2023)

Roles of gut microbiota in atrial fibrillation: insights from Mendelian randomization analysis and genetic data from over 430,000 cohort study participants
por: Dai, Huajie, et al.
Publicado: (2023)

Arterial Stiffness, Biomarkers of Liver Fat, and the Development of Metabolic Dysfunction in Metabolically Healthy Population: A Prospective Study
por: Lin, Lin, et al.
Publicado: (2022)

Impact of Genetically Predicted Red Blood Cell Traits on Venous Thromboembolism: Multivariable Mendelian Randomization Study Using UK Biobank
por: Luo, Shan, et al.
Publicado: (2020)

Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study
por: Xu, Min, et al.
Publicado: (2016)

Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank
por: Luo, Shan, et al.
Publicado: (2019)

Nonalcoholic fatty liver disease in relation to the remission and progression along the glycemic continuum
por: Xin, Zhuojun, et al.
Publicado: (2022)

Risk of subclinical atherosclerosis across metabolic transition in individuals with or without fatty liver disease: a prospective cohort study
por: Xin, Zhuojun, et al.
Publicado: (2023)

Individual and Combined Associations of Glucose Metabolic Components With Cognitive Function Modified by Obesity
por: He, Ruixin, et al.
Publicado: (2021)

Genetic susceptibility, family history of diabetes and healthy lifestyle factors in relation to diabetes: A gene–environment interaction analysis in Chinese adults
por: Ye, Chaojie, et al.
Publicado: (2021)

Awareness, treatment and control of cardiometabolic disorders in Chinese adults with diabetes: a national representative population study
por: Wang, Tiange, et al.
Publicado: (2015)

Age-specific difference in the association between prediabetes and subclinical atherosclerosis: an analysis of a chinese prospective cohort study
por: Cao, Qiuyu, et al.
Publicado: (2022)

Age-specific prevalence, subtypes and risk factors of metabolic diseases in Chinese adults and the different patterns from other racial/ethnic populations
por: Cao, Qiuyu, et al.
Publicado: (2022)

Evaluation of glycemic traits in susceptibility to COVID-19 risk: a Mendelian randomization study
por: Au Yeung, Shiu Lun, et al.
Publicado: (2021)

Association of genetically predicted blood sucrose with coronary heart disease and its risk factors in Mendelian randomization
por: Zhang, Ting, et al.
Publicado: (2020)

Pan‐risk factor for a comprehensive cardiovascular health management
por: Zheng, Ruizhi, et al.
Publicado: (2022)

Sex differences in the association of fasting glucose with HbA1c, and their consequences for mortality: A Mendelian randomization study
por: Yang, Guoyi, et al.
Publicado: (2022)

Thyroid hormones associate with risk of incident chronic kidney disease and rapid decline in renal function: a prospective investigation
por: Huang, Xiaolin, et al.
Publicado: (2016)

Association of Early and Supernormal Vascular Aging categories with cardiovascular disease in the Chinese population
por: Cao, Qiuyu, et al.
Publicado: (2022)

Association between serum LDL‐C concentrations and risk of diabetes: A prospective cohort study
por: Huang, Jiaojiao, et al.
Publicado: (2023)

Birth weight and risk of ischemic heart disease: A Mendelian randomization study
por: Au Yeung, Shiu Lun, et al.
Publicado: (2016)

Hypertriglyceridemic hyperapoB and the development and resolution of nonalcoholic fatty liver disease: a cohort study
por: Wang, Yiying, et al.
Publicado: (2023)

Additional Cover
por: Ye, Chaojie, et al.
Publicado: (2023)

Associations of Arachidonic Acid Synthesis with Cardiovascular Risk Factors and Relation to Ischemic Heart Disease and Stroke: A Univariable and Multivariable Mendelian Randomization Study
por: Zhang, Ting, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9uesv5g43be7mbfi4u2ntebld8