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Transient conformations in the unliganded FK506 binding domain of FKBP51 correspond to two distinct inhibitor-bound states
Members of the FK506-binding protein (FKBP) family regulate a range of important physiological processes. Unfortunately, current therapeutics such as FK506 and rapamycin exhibit only modest selectivity among these functionally distinct proteins. Recent progress in developing selective inhibitors has...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514456/ https://www.ncbi.nlm.nih.gov/pubmed/37579948 http://dx.doi.org/10.1016/j.jbc.2023.105159 |