Characterization of a novel inhibitor for the New Delhi metallo-β-lactamase-4: Implications for drug design and combating bacterial drug resistance

The bacterial metallo-β-lactamases (MBLs) catalyze the inactivation of β-lactam antibiotics. Identifying novel pharmacophores remains crucial for the clinical development of additional MBL inhibitors. Previously, 1-hydroxypyridine-2(1H)-thione-6-carboxylic acid, hereafter referred to as 1,2-HPT-6-CO...

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Detalles Bibliográficos
Autores principales: Thoden, James B., Benin, Bogdan M., Priebe, Adam, Shin, Woo Shik, Muthyala, Ramaiah, Sham, Yuk Yin, Holden, Hazel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514461/
https://www.ncbi.nlm.nih.gov/pubmed/37549809
http://dx.doi.org/10.1016/j.jbc.2023.105135

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