Cargando…
Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults
Successful explicit memory encoding is associated with inferior temporal activations and medial parietal deactivations, which are attenuated in aging. Here we used dynamic causal modeling (DCM) of functional magnetic resonance imaging data to elucidate effective connectivity patterns between hippoca...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514462/ https://www.ncbi.nlm.nih.gov/pubmed/37744028 http://dx.doi.org/10.1016/j.isci.2023.107765 |
_version_ | 1785108733842423808 |
---|---|
author | Schott, Björn H. Soch, Joram Kizilirmak, Jasmin M. Schütze, Hartmut Assmann, Anne Maass, Anne Ziegler, Gabriel Sauvage, Magdalena Richter, Anni |
author_facet | Schott, Björn H. Soch, Joram Kizilirmak, Jasmin M. Schütze, Hartmut Assmann, Anne Maass, Anne Ziegler, Gabriel Sauvage, Magdalena Richter, Anni |
author_sort | Schott, Björn H. |
collection | PubMed |
description | Successful explicit memory encoding is associated with inferior temporal activations and medial parietal deactivations, which are attenuated in aging. Here we used dynamic causal modeling (DCM) of functional magnetic resonance imaging data to elucidate effective connectivity patterns between hippocampus, parahippocampal place area (PPA), and precuneus during encoding of novel visual scenes. In 117 young adults, DCM revealed pronounced activating input from the PPA to the hippocampus and inhibitory connectivity from the PPA to the precuneus during novelty processing, with both being enhanced during successful encoding. This pattern could be replicated in two cohorts (N = 141 and 148) of young and older adults. In both cohorts, older adults selectively exhibited attenuated inhibitory PPA-precuneus connectivity, which correlated negatively with memory performance. Our results provide insight into the network dynamics underlying explicit memory encoding and suggest that age-related differences in memory-related network activity are, at least partly, attributable to altered temporo-parietal neocortical connectivity. |
format | Online Article Text |
id | pubmed-10514462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105144622023-09-23 Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults Schott, Björn H. Soch, Joram Kizilirmak, Jasmin M. Schütze, Hartmut Assmann, Anne Maass, Anne Ziegler, Gabriel Sauvage, Magdalena Richter, Anni iScience Article Successful explicit memory encoding is associated with inferior temporal activations and medial parietal deactivations, which are attenuated in aging. Here we used dynamic causal modeling (DCM) of functional magnetic resonance imaging data to elucidate effective connectivity patterns between hippocampus, parahippocampal place area (PPA), and precuneus during encoding of novel visual scenes. In 117 young adults, DCM revealed pronounced activating input from the PPA to the hippocampus and inhibitory connectivity from the PPA to the precuneus during novelty processing, with both being enhanced during successful encoding. This pattern could be replicated in two cohorts (N = 141 and 148) of young and older adults. In both cohorts, older adults selectively exhibited attenuated inhibitory PPA-precuneus connectivity, which correlated negatively with memory performance. Our results provide insight into the network dynamics underlying explicit memory encoding and suggest that age-related differences in memory-related network activity are, at least partly, attributable to altered temporo-parietal neocortical connectivity. Elsevier 2023-08-29 /pmc/articles/PMC10514462/ /pubmed/37744028 http://dx.doi.org/10.1016/j.isci.2023.107765 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Schott, Björn H. Soch, Joram Kizilirmak, Jasmin M. Schütze, Hartmut Assmann, Anne Maass, Anne Ziegler, Gabriel Sauvage, Magdalena Richter, Anni Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults |
title | Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults |
title_full | Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults |
title_fullStr | Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults |
title_full_unstemmed | Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults |
title_short | Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults |
title_sort | inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514462/ https://www.ncbi.nlm.nih.gov/pubmed/37744028 http://dx.doi.org/10.1016/j.isci.2023.107765 |
work_keys_str_mv | AT schottbjornh inhibitorytemporoparietaleffectiveconnectivityisassociatedwithexplicitmemoryperformanceinolderadults AT sochjoram inhibitorytemporoparietaleffectiveconnectivityisassociatedwithexplicitmemoryperformanceinolderadults AT kizilirmakjasminm inhibitorytemporoparietaleffectiveconnectivityisassociatedwithexplicitmemoryperformanceinolderadults AT schutzehartmut inhibitorytemporoparietaleffectiveconnectivityisassociatedwithexplicitmemoryperformanceinolderadults AT assmannanne inhibitorytemporoparietaleffectiveconnectivityisassociatedwithexplicitmemoryperformanceinolderadults AT maassanne inhibitorytemporoparietaleffectiveconnectivityisassociatedwithexplicitmemoryperformanceinolderadults AT zieglergabriel inhibitorytemporoparietaleffectiveconnectivityisassociatedwithexplicitmemoryperformanceinolderadults AT sauvagemagdalena inhibitorytemporoparietaleffectiveconnectivityisassociatedwithexplicitmemoryperformanceinolderadults AT richteranni inhibitorytemporoparietaleffectiveconnectivityisassociatedwithexplicitmemoryperformanceinolderadults |