Hydrogen peroxide-dependent oxidation of ERK2 within its D-recruitment site alters its substrate selection

Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are dysregulated in many pervasive diseases. Recently, we discovered that ERK1/2 is oxidized by signal-generated hydrogen peroxide in various cell types. Since the putative sites of oxidation lie within or near ERK1/2’s ligand-binding surfaces,...

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Detalles Bibliográficos
Autores principales: Postiglione, Anthony E., Adams, Laquaundra L., Ekhator, Ese S., Odelade, Anuoluwapo E., Patwardhan, Supriya, Chaudhari, Meenal, Pardue, Avery S., Kumari, Anjali, LeFever, William A., Tornow, Olivia P., Kaoud, Tamer S., Neiswinger, Johnathan, Jeong, Jun Seop, Parsonage, Derek, Nelson, Kimberly J., Kc, Dukka B., Furdui, Cristina M., Zhu, Heng, Wommack, Andrew J., Dalby, Kevin N., Dong, Ming, Poole, Leslie B., Keyes, Jeremiah D., Newman, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514464/
https://www.ncbi.nlm.nih.gov/pubmed/37744034
http://dx.doi.org/10.1016/j.isci.2023.107817

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