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Gene presence/absence variation in Mytilus galloprovincialis and its implications in gene expression and adaptation

Presence/absence variation (PAV) is a well-known phenomenon in prokaryotes that was described for the first time in bivalves in 2020 in Mytilus galloprovincialis. The objective of the present study was to further our understanding of the PAV phenomenon in mussel biology. The distribution of PAV was...

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Autores principales: Saco, Amaro, Rey-Campos, Magalí, Gallardo-Escárate, Cristian, Gerdol, Marco, Novoa, Beatriz, Figueras, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514466/
https://www.ncbi.nlm.nih.gov/pubmed/37744033
http://dx.doi.org/10.1016/j.isci.2023.107827
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author Saco, Amaro
Rey-Campos, Magalí
Gallardo-Escárate, Cristian
Gerdol, Marco
Novoa, Beatriz
Figueras, Antonio
author_facet Saco, Amaro
Rey-Campos, Magalí
Gallardo-Escárate, Cristian
Gerdol, Marco
Novoa, Beatriz
Figueras, Antonio
author_sort Saco, Amaro
collection PubMed
description Presence/absence variation (PAV) is a well-known phenomenon in prokaryotes that was described for the first time in bivalves in 2020 in Mytilus galloprovincialis. The objective of the present study was to further our understanding of the PAV phenomenon in mussel biology. The distribution of PAV was studied in a mussel chromosome-level genome assembly, revealing a widespread distribution but with hotspots of dispensability. Special attention was given to the effect of PAV in gene expression, since dispensable genes were found to be inherently subject to distortions due to their sparse distribution among individuals. Furthermore, the high expression and strong tissue specificity of some dispensable genes, such as myticins, strongly supported their biological relevance. The significant differences in the repertoire of dispensable genes associated with two geographically distinct populations suggest that PAV is involved in local adaptation. Overall, the PAV phenomenon would provide a key selective advantage at the population level.
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spelling pubmed-105144662023-09-23 Gene presence/absence variation in Mytilus galloprovincialis and its implications in gene expression and adaptation Saco, Amaro Rey-Campos, Magalí Gallardo-Escárate, Cristian Gerdol, Marco Novoa, Beatriz Figueras, Antonio iScience Article Presence/absence variation (PAV) is a well-known phenomenon in prokaryotes that was described for the first time in bivalves in 2020 in Mytilus galloprovincialis. The objective of the present study was to further our understanding of the PAV phenomenon in mussel biology. The distribution of PAV was studied in a mussel chromosome-level genome assembly, revealing a widespread distribution but with hotspots of dispensability. Special attention was given to the effect of PAV in gene expression, since dispensable genes were found to be inherently subject to distortions due to their sparse distribution among individuals. Furthermore, the high expression and strong tissue specificity of some dispensable genes, such as myticins, strongly supported their biological relevance. The significant differences in the repertoire of dispensable genes associated with two geographically distinct populations suggest that PAV is involved in local adaptation. Overall, the PAV phenomenon would provide a key selective advantage at the population level. Elsevier 2023-09-04 /pmc/articles/PMC10514466/ /pubmed/37744033 http://dx.doi.org/10.1016/j.isci.2023.107827 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Saco, Amaro
Rey-Campos, Magalí
Gallardo-Escárate, Cristian
Gerdol, Marco
Novoa, Beatriz
Figueras, Antonio
Gene presence/absence variation in Mytilus galloprovincialis and its implications in gene expression and adaptation
title Gene presence/absence variation in Mytilus galloprovincialis and its implications in gene expression and adaptation
title_full Gene presence/absence variation in Mytilus galloprovincialis and its implications in gene expression and adaptation
title_fullStr Gene presence/absence variation in Mytilus galloprovincialis and its implications in gene expression and adaptation
title_full_unstemmed Gene presence/absence variation in Mytilus galloprovincialis and its implications in gene expression and adaptation
title_short Gene presence/absence variation in Mytilus galloprovincialis and its implications in gene expression and adaptation
title_sort gene presence/absence variation in mytilus galloprovincialis and its implications in gene expression and adaptation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514466/
https://www.ncbi.nlm.nih.gov/pubmed/37744033
http://dx.doi.org/10.1016/j.isci.2023.107827
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