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Molecular dynamics simulations support a multistep pathway for activation of branched actin filament nucleation by Arp2/3 complex

Actin-related protein 2/3 complex (Arp2/3 complex) catalyzes the nucleation of branched actin filaments that push against membranes in processes like cellular motility and endocytosis. During activation by WASP proteins, the complex must bind WASP and engage the side of a pre-existing (mother) filam...

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Detalles Bibliográficos
Autores principales:	Singh, Yuvraj, Hocky, Glen M., Nolen, Brad J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514467/ https://www.ncbi.nlm.nih.gov/pubmed/37595874 http://dx.doi.org/10.1016/j.jbc.2023.105169

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