Reduced ER-mitochondrial contact sites and mitochondrial Ca(2+) flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines

Endoplasmic reticulum-mitochondrial contact sites (ERMCS) play an important role in mitochondrial dynamics, calcium signaling, and autophagy. Disruption of the ERMCS has been linked to several neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic l...

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Detalles Bibliográficos
Autores principales: Yokota, Mutsumi, Yoshino, Yutaro, Hosoi, Mitsuko, Hashimoto, Ryota, Kakuta, Soichiro, Shiga, Takahiro, Ishikawa, Kei-Ichi, Okano, Hideyuki, Hattori, Nobutaka, Akamatsu, Wado, Koike, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514478/
https://www.ncbi.nlm.nih.gov/pubmed/37745304
http://dx.doi.org/10.3389/fcell.2023.1171440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514478/
https://www.ncbi.nlm.nih.gov/pubmed/37745304
http://dx.doi.org/10.3389/fcell.2023.1171440

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