Cargando…

Reduced ER-mitochondrial contact sites and mitochondrial Ca(2+) flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines

Endoplasmic reticulum-mitochondrial contact sites (ERMCS) play an important role in mitochondrial dynamics, calcium signaling, and autophagy. Disruption of the ERMCS has been linked to several neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yokota, Mutsumi, Yoshino, Yutaro, Hosoi, Mitsuko, Hashimoto, Ryota, Kakuta, Soichiro, Shiga, Takahiro, Ishikawa, Kei-Ichi, Okano, Hideyuki, Hattori, Nobutaka, Akamatsu, Wado, Koike, Masato
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514478/ https://www.ncbi.nlm.nih.gov/pubmed/37745304 http://dx.doi.org/10.3389/fcell.2023.1171440

Ejemplares similares

Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons
por: Yokota, Mutsumi, et al.
Publicado: (2021)

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
por: Imaizumi, Yoichi, et al.
Publicado: (2012)

Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells
por: Fujimori, Koki, et al.
Publicado: (2017)

Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations
por: Kano, Masayoshi, et al.
Publicado: (2020)

Long-read sequencing resolves a complex structural variant in PRKN Parkinson’s disease
por: Daida, Kensuke, et al.
Publicado: (2023)

Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson’s disease
por: Trinh, Joanne, et al.
Publicado: (2022)

Mitochondrial replacement in an iPSC model of Leber's hereditary optic neuropathy
por: Wong, Raymond C.B., et al.
Publicado: (2017)

Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling
por: Imaizumi, Kent, et al.
Publicado: (2018)

Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism
por: Borsche, Max, et al.
Publicado: (2020)

Involvement of ER Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by iPSC-Derived Oligodendrocytes
por: Numasawa-Kuroiwa, Yuko, et al.
Publicado: (2014)

Involvement of ER Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by iPSC-Derived Oligodendrocytes
por: Numasawa-Kuroiwa, Yuko, et al.
Publicado: (2015)

Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies
por: Wang, Gang, et al.
Publicado: (2014)

Mitochondrial respiratory dysfunction disturbs neuronal and cardiac lineage commitment of human iPSCs
por: Yokota, Mutsumi, et al.
Publicado: (2017)

Molecular phenotypes of mitochondrial dysfunction in clinically non-manifesting heterozygous PRKN variant carriers
por: Castelo Rueda, Maria Paulina, et al.
Publicado: (2023)

A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson’s disease
por: Nakamura, Ryota, et al.
Publicado: (2023)

Astrocytes Attenuate Mitochondrial Dysfunctions in Human Dopaminergic Neurons Derived from iPSC
por: Du, Fang, et al.
Publicado: (2018)

Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation
por: Yao, Yin, et al.
Publicado: (2018)

iPSC culture expansion selects against putatively actionable mutations in the mitochondrial genome
por: Kosanke, Maike, et al.
Publicado: (2021)

miR-218 Inhibits Mitochondrial Clearance by Targeting PRKN E3 Ubiquitin Ligase
por: Di Rita, Anthea, et al.
Publicado: (2020)

Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes
por: Imaizumi, Kent, et al.
Publicado: (2015)

Mitochondrial Dysregulation and Impaired Autophagy in iPSC-Derived Dopaminergic Neurons of Multiple System Atrophy
por: Monzio Compagnoni, Giacomo, et al.
Publicado: (2018)

Mitochondrial Phenotypes in Parkinson’s Diseases—A Focus on Human iPSC-Derived Dopaminergic Neurons
por: Heger, Leonie M., et al.
Publicado: (2021)

Cell type and sex specific mitochondrial phenotypes in iPSC derived models of Alzheimer’s disease
por: Flannagan, Kaitlin, et al.
Publicado: (2023)

Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease
por: Koinuma, Takahiro, et al.
Publicado: (2021)

Regenerative therapy for spinal cord injury using iPSC technology
por: Nagoshi, Narihito, et al.
Publicado: (2020)

iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function
por: Ni, Peiyan, et al.
Publicado: (2019)

Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders
por: Osete, Jordi Requena, et al.
Publicado: (2021)

Testing Mitochondrial-Targeted Drugs in iPSC-RPE from Patients with Age-Related Macular Degeneration
por: Ebeling, Mara C., et al.
Publicado: (2022)

Metabolic rescue ameliorates mitochondrial encephalo‐cardiomyopathy in murine and human iPSC models of Leigh syndrome
por: Yoon, Jin‐Young, et al.
Publicado: (2022)

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons
por: Beccano-Kelly, Dayne A., et al.
Publicado: (2023)

Mitochondrial Dysfunctions Contribute to Hypertrophic Cardiomyopathy in Patient iPSC-Derived Cardiomyocytes with MT-RNR2 Mutation
por: Li, Shishi, et al.
Publicado: (2018)

Calpain Inhibition Restores Autophagy and Prevents Mitochondrial Fragmentation in a Human iPSC Model of Diabetic Endotheliopathy
por: Ong, Sang-Bing, et al.
Publicado: (2019)

Mitochondrial biogenesis and neural differentiation of human iPSC is modulated by idebenone in a developmental stage-dependent manner
por: Augustyniak, J., et al.
Publicado: (2017)

Zinc Oxide Nanoparticles Induce Mitochondrial Biogenesis Impairment and Cardiac Dysfunction in Human iPSC-Derived Cardiomyocytes
por: Li, Yujie, et al.
Publicado: (2020)

Modeling of mitochondrial bioenergetics and autophagy impairment in MELAS-mutant iPSC-derived retinal pigment epithelial cells
por: Bhattacharya, Sujoy, et al.
Publicado: (2022)

Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease
por: Yamaguchi, Akihiro, et al.
Publicado: (2020)

Genomic, transcriptomic, and metabolomic profiles of hiPSC-derived dopamine neurons from clinically discordant brothers with identical PRKN deletions
por: Cukier, Holly N., et al.
Publicado: (2022)

Banking on iPSC- Is it Doable and is it Worthwhile
por: Solomon, Susan, et al.
Publicado: (2014)

Roadblocks in the Path of iPSC to the Clinic
por: Garreta, Elena, et al.
Publicado: (2018)

iPSC Bioprinting: Where are We at?
por: Romanazzo, Sara, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_j2opavcscg2r3blfdcrtpuvn3e