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Fibrinogen-to-albumin ratio predicts overall survival of hepatocellular carcinoma

BACKGROUND: Fibrinogen-to-albumin ratio (FAR) has been found to be of prognostic significance for several types of malignant tumors. However, less is known about the association between FAR and survival outcomes in hepatocellular carcinoma (HCC) patients. AIM: To explore the association between FAR...

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Autores principales: Sun, Hao, Ma, Jie, Lu, Jian, Yao, Zhi-Hong, Ran, Hai-Liang, Zhou, Hai, Yuan, Zhong-Qin, Huang, Yun-Chao, Xiao, Yuan-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514720/
https://www.ncbi.nlm.nih.gov/pubmed/37746650
http://dx.doi.org/10.4251/wjgo.v15.i9.1662
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author Sun, Hao
Ma, Jie
Lu, Jian
Yao, Zhi-Hong
Ran, Hai-Liang
Zhou, Hai
Yuan, Zhong-Qin
Huang, Yun-Chao
Xiao, Yuan-Yuan
author_facet Sun, Hao
Ma, Jie
Lu, Jian
Yao, Zhi-Hong
Ran, Hai-Liang
Zhou, Hai
Yuan, Zhong-Qin
Huang, Yun-Chao
Xiao, Yuan-Yuan
author_sort Sun, Hao
collection PubMed
description BACKGROUND: Fibrinogen-to-albumin ratio (FAR) has been found to be of prognostic significance for several types of malignant tumors. However, less is known about the association between FAR and survival outcomes in hepatocellular carcinoma (HCC) patients. AIM: To explore the association between FAR and prognosis and survival in patients with HCC. METHODS: A total of 366 histologically confirmed HCC patients diagnosed between 2013 and 2018 in a provincial cancer hospital in southwestern China were retrospectively selected. Relevant data were extracted from the hospital information system. The optimal cutoff for baseline serum FAR measured upon disease diagnosis was established using the receiver operating characteristic (ROC) curve. Univariate and multivariate Cox proportional hazards models were used to determine the crude and adjusted associations between FAR and the overall survival (OS) of the HCC patients while controlling for various covariates. The restricted cubic spline (RCS) was applied to estimate the dose-response trend in the FAR-OS association. RESULTS: The optimal cutoff value for baseline FAR determined by the ROC was 0.081. Multivariate Cox proportional hazards model revealed that a lower baseline serum FAR level was associated with an adjusted hazard ratio of 2.43 (95% confidence interval: 1.87–3.15) in the OS of HCC patients, with identifiable dose-response trend in the RCS. Subgroup analysis showed that this FAR-OS association was more prominent in HCC patients with a lower baseline serum aspartate aminotransferase or carbohydrate antigen 125 level. CONCLUSION: Serum FAR is a prominent prognostic indicator for HCC. Intervention measures aimed at reducing FAR might result in survival benefit for HCC patients.
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spelling pubmed-105147202023-09-23 Fibrinogen-to-albumin ratio predicts overall survival of hepatocellular carcinoma Sun, Hao Ma, Jie Lu, Jian Yao, Zhi-Hong Ran, Hai-Liang Zhou, Hai Yuan, Zhong-Qin Huang, Yun-Chao Xiao, Yuan-Yuan World J Gastrointest Oncol Observational Study BACKGROUND: Fibrinogen-to-albumin ratio (FAR) has been found to be of prognostic significance for several types of malignant tumors. However, less is known about the association between FAR and survival outcomes in hepatocellular carcinoma (HCC) patients. AIM: To explore the association between FAR and prognosis and survival in patients with HCC. METHODS: A total of 366 histologically confirmed HCC patients diagnosed between 2013 and 2018 in a provincial cancer hospital in southwestern China were retrospectively selected. Relevant data were extracted from the hospital information system. The optimal cutoff for baseline serum FAR measured upon disease diagnosis was established using the receiver operating characteristic (ROC) curve. Univariate and multivariate Cox proportional hazards models were used to determine the crude and adjusted associations between FAR and the overall survival (OS) of the HCC patients while controlling for various covariates. The restricted cubic spline (RCS) was applied to estimate the dose-response trend in the FAR-OS association. RESULTS: The optimal cutoff value for baseline FAR determined by the ROC was 0.081. Multivariate Cox proportional hazards model revealed that a lower baseline serum FAR level was associated with an adjusted hazard ratio of 2.43 (95% confidence interval: 1.87–3.15) in the OS of HCC patients, with identifiable dose-response trend in the RCS. Subgroup analysis showed that this FAR-OS association was more prominent in HCC patients with a lower baseline serum aspartate aminotransferase or carbohydrate antigen 125 level. CONCLUSION: Serum FAR is a prominent prognostic indicator for HCC. Intervention measures aimed at reducing FAR might result in survival benefit for HCC patients. Baishideng Publishing Group Inc 2023-09-15 2023-09-15 /pmc/articles/PMC10514720/ /pubmed/37746650 http://dx.doi.org/10.4251/wjgo.v15.i9.1662 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Observational Study
Sun, Hao
Ma, Jie
Lu, Jian
Yao, Zhi-Hong
Ran, Hai-Liang
Zhou, Hai
Yuan, Zhong-Qin
Huang, Yun-Chao
Xiao, Yuan-Yuan
Fibrinogen-to-albumin ratio predicts overall survival of hepatocellular carcinoma
title Fibrinogen-to-albumin ratio predicts overall survival of hepatocellular carcinoma
title_full Fibrinogen-to-albumin ratio predicts overall survival of hepatocellular carcinoma
title_fullStr Fibrinogen-to-albumin ratio predicts overall survival of hepatocellular carcinoma
title_full_unstemmed Fibrinogen-to-albumin ratio predicts overall survival of hepatocellular carcinoma
title_short Fibrinogen-to-albumin ratio predicts overall survival of hepatocellular carcinoma
title_sort fibrinogen-to-albumin ratio predicts overall survival of hepatocellular carcinoma
topic Observational Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514720/
https://www.ncbi.nlm.nih.gov/pubmed/37746650
http://dx.doi.org/10.4251/wjgo.v15.i9.1662
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