Cargando…

Effect of Oral High Molecular Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D Supplementation in Pregnant Women: A Retrospective Observational Pilot Study

Background—Pregnancy represents a nutritional challenge, since macro- and micronutrients intake can affect mother’ health and influence negative outcomes. The aim of this retrospective pilot study is to evidence whether the oral supplementation with high molecular weight hyaluronic acid (HMWHA), in...

Descripción completa

Detalles Bibliográficos
Autores principales: Parente, Eligio, Colannino, Giulia, Bilotta, Gabriele, Espinola, Maria Salomé Bezerra, Proietti, Sara, Oliva, Mario Montanino, Neri, Isabella, Aragona, Cesare, Unfer, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514820/
https://www.ncbi.nlm.nih.gov/pubmed/37736936
http://dx.doi.org/10.3390/clinpract13050100
_version_ 1785108808794636288
author Parente, Eligio
Colannino, Giulia
Bilotta, Gabriele
Espinola, Maria Salomé Bezerra
Proietti, Sara
Oliva, Mario Montanino
Neri, Isabella
Aragona, Cesare
Unfer, Vittorio
author_facet Parente, Eligio
Colannino, Giulia
Bilotta, Gabriele
Espinola, Maria Salomé Bezerra
Proietti, Sara
Oliva, Mario Montanino
Neri, Isabella
Aragona, Cesare
Unfer, Vittorio
author_sort Parente, Eligio
collection PubMed
description Background—Pregnancy represents a nutritional challenge, since macro- and micronutrients intake can affect mother’ health and influence negative outcomes. The aim of this retrospective pilot study is to evidence whether the oral supplementation with high molecular weight hyaluronic acid (HMWHA), in association with alpha lipoic acid (ALA), magnesium, vitamin B6 and vitamin D, in pregnant women, could reduce adverse effects, such as PTB, pelvic pain, contraction and hospitalization. Methods—Data were collected from n = 200 women treated daily with oral supplements of 200 mg HMWHA, 100 mg ALA, 450 mg magnesium, 2.6 mg vitamin B6 and 50 mcg vitamin D (treatment group) and from n = 50 women taking with oral supplements of 400 mg magnesium (control group). In both groups, supplementation started from the 7th gestational week until delivery. Results—Oral treatment with HMWHA, in association with ALA, magnesium, vitamin B6 and vitamin D in pregnant women, significantly reduced adverse events, such as PTB (p < 0.01), pelvic pain and contractions (p < 0.0001), miscarriages (p < 0.05) and admission to ER/hospitalization (p < 0.0001) compared with the control group. Conclusions—Despite HMWHA having been poorly used as a food supplement in pregnant women, our results open a reassuring scenario regarding its oral administration during pregnancy.
format Online
Article
Text
id pubmed-10514820
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105148202023-09-23 Effect of Oral High Molecular Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D Supplementation in Pregnant Women: A Retrospective Observational Pilot Study Parente, Eligio Colannino, Giulia Bilotta, Gabriele Espinola, Maria Salomé Bezerra Proietti, Sara Oliva, Mario Montanino Neri, Isabella Aragona, Cesare Unfer, Vittorio Clin Pract Brief Report Background—Pregnancy represents a nutritional challenge, since macro- and micronutrients intake can affect mother’ health and influence negative outcomes. The aim of this retrospective pilot study is to evidence whether the oral supplementation with high molecular weight hyaluronic acid (HMWHA), in association with alpha lipoic acid (ALA), magnesium, vitamin B6 and vitamin D, in pregnant women, could reduce adverse effects, such as PTB, pelvic pain, contraction and hospitalization. Methods—Data were collected from n = 200 women treated daily with oral supplements of 200 mg HMWHA, 100 mg ALA, 450 mg magnesium, 2.6 mg vitamin B6 and 50 mcg vitamin D (treatment group) and from n = 50 women taking with oral supplements of 400 mg magnesium (control group). In both groups, supplementation started from the 7th gestational week until delivery. Results—Oral treatment with HMWHA, in association with ALA, magnesium, vitamin B6 and vitamin D in pregnant women, significantly reduced adverse events, such as PTB (p < 0.01), pelvic pain and contractions (p < 0.0001), miscarriages (p < 0.05) and admission to ER/hospitalization (p < 0.0001) compared with the control group. Conclusions—Despite HMWHA having been poorly used as a food supplement in pregnant women, our results open a reassuring scenario regarding its oral administration during pregnancy. MDPI 2023-09-15 /pmc/articles/PMC10514820/ /pubmed/37736936 http://dx.doi.org/10.3390/clinpract13050100 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Parente, Eligio
Colannino, Giulia
Bilotta, Gabriele
Espinola, Maria Salomé Bezerra
Proietti, Sara
Oliva, Mario Montanino
Neri, Isabella
Aragona, Cesare
Unfer, Vittorio
Effect of Oral High Molecular Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D Supplementation in Pregnant Women: A Retrospective Observational Pilot Study
title Effect of Oral High Molecular Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D Supplementation in Pregnant Women: A Retrospective Observational Pilot Study
title_full Effect of Oral High Molecular Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D Supplementation in Pregnant Women: A Retrospective Observational Pilot Study
title_fullStr Effect of Oral High Molecular Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D Supplementation in Pregnant Women: A Retrospective Observational Pilot Study
title_full_unstemmed Effect of Oral High Molecular Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D Supplementation in Pregnant Women: A Retrospective Observational Pilot Study
title_short Effect of Oral High Molecular Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D Supplementation in Pregnant Women: A Retrospective Observational Pilot Study
title_sort effect of oral high molecular weight hyaluronic acid (hmwha), alpha lipoic acid (ala), magnesium, vitamin b6 and vitamin d supplementation in pregnant women: a retrospective observational pilot study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514820/
https://www.ncbi.nlm.nih.gov/pubmed/37736936
http://dx.doi.org/10.3390/clinpract13050100
work_keys_str_mv AT parenteeligio effectoforalhighmolecularweighthyaluronicacidhmwhaalphalipoicacidalamagnesiumvitaminb6andvitamindsupplementationinpregnantwomenaretrospectiveobservationalpilotstudy
AT colanninogiulia effectoforalhighmolecularweighthyaluronicacidhmwhaalphalipoicacidalamagnesiumvitaminb6andvitamindsupplementationinpregnantwomenaretrospectiveobservationalpilotstudy
AT bilottagabriele effectoforalhighmolecularweighthyaluronicacidhmwhaalphalipoicacidalamagnesiumvitaminb6andvitamindsupplementationinpregnantwomenaretrospectiveobservationalpilotstudy
AT espinolamariasalomebezerra effectoforalhighmolecularweighthyaluronicacidhmwhaalphalipoicacidalamagnesiumvitaminb6andvitamindsupplementationinpregnantwomenaretrospectiveobservationalpilotstudy
AT proiettisara effectoforalhighmolecularweighthyaluronicacidhmwhaalphalipoicacidalamagnesiumvitaminb6andvitamindsupplementationinpregnantwomenaretrospectiveobservationalpilotstudy
AT olivamariomontanino effectoforalhighmolecularweighthyaluronicacidhmwhaalphalipoicacidalamagnesiumvitaminb6andvitamindsupplementationinpregnantwomenaretrospectiveobservationalpilotstudy
AT neriisabella effectoforalhighmolecularweighthyaluronicacidhmwhaalphalipoicacidalamagnesiumvitaminb6andvitamindsupplementationinpregnantwomenaretrospectiveobservationalpilotstudy
AT aragonacesare effectoforalhighmolecularweighthyaluronicacidhmwhaalphalipoicacidalamagnesiumvitaminb6andvitamindsupplementationinpregnantwomenaretrospectiveobservationalpilotstudy
AT unfervittorio effectoforalhighmolecularweighthyaluronicacidhmwhaalphalipoicacidalamagnesiumvitaminb6andvitamindsupplementationinpregnantwomenaretrospectiveobservationalpilotstudy