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Inverse-Folding Design of Yeast Telomerase RNA Increases Activity In Vitro

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Saccharomyces cerevisiae telomerase RNA, TLC1, is an 1157 nt non-coding RNA that functions as both a template for DNA synthesis and a flexible scaffold for telomerase RNP holoenzyme protein subunits. The tractable budding yeast system has provided landmark discoveries about telomere biology in vivo,...

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Detalles Bibliográficos
Autores principales:	Lebo, Kevin J., Zappulla, David C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514824/ https://www.ncbi.nlm.nih.gov/pubmed/37736897 http://dx.doi.org/10.3390/ncrna9050051

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