Cargando…

Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol

In pregnancies complicated by sickle cell disease (SCD), the maternal-fetal dyad is at high risk for mortality and morbidity. In healthy pregnancies, maternal nutritional status is a critical factor for the healthy growth and development of the fetus. However, there are no reviews of the current res...

Descripción completa

Detalles Bibliográficos
Autores principales: Klein, Lauren J., Ayete-Nyampong, John Benaiah, Williams, Annette M., Harding, Lori A., Oppong, Samuel A., Acra, Sari, DeBaun, Michael R., Imdad, Aamer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514847/
https://www.ncbi.nlm.nih.gov/pubmed/37736971
http://dx.doi.org/10.3390/mps6050088
_version_ 1785108815172075520
author Klein, Lauren J.
Ayete-Nyampong, John Benaiah
Williams, Annette M.
Harding, Lori A.
Oppong, Samuel A.
Acra, Sari
DeBaun, Michael R.
Imdad, Aamer
author_facet Klein, Lauren J.
Ayete-Nyampong, John Benaiah
Williams, Annette M.
Harding, Lori A.
Oppong, Samuel A.
Acra, Sari
DeBaun, Michael R.
Imdad, Aamer
author_sort Klein, Lauren J.
collection PubMed
description In pregnancies complicated by sickle cell disease (SCD), the maternal-fetal dyad is at high risk for mortality and morbidity. In healthy pregnancies, maternal nutritional status is a critical factor for the healthy growth and development of the fetus. However, there are no reviews of the current research on the nutritional status of pregnant women with SCD and pregnancy outcomes. First, we aim to assess the burden of malnutrition in pregnant women with SCD. Next, we aim to systematically evaluate if pregnant women with SCD who have poor nutritional status are at increased risk for adverse birth outcomes compared to pregnant women with sickle cell disease and normal nutritional status. We will systematically search multiple electronic databases. Our exposure is pregnant women with SCD and poor nutritional status. The primary outcomes of interest include low birth weight (categorical) and birth weight z-scores (continuous). We will also evaluate maternal and perinatal outcomes as secondary outcomes. We will evaluate the risk of bias and overall certainty of evidence with Risk of Bias in Non-randomized Studies—of Interventions (ROBINS-I), and the overall evidence will be assessed using Grading of Recommendation Assessment, Development, and Evaluation (GRADE) criteria. We will pool findings with a meta-analysis if sufficient homogeneity exists among studies. Findings will be published in a peer-reviewed journal and disseminated to SCD advocacy groups. PROSPERO registration number: 429412.
format Online
Article
Text
id pubmed-10514847
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105148472023-09-23 Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol Klein, Lauren J. Ayete-Nyampong, John Benaiah Williams, Annette M. Harding, Lori A. Oppong, Samuel A. Acra, Sari DeBaun, Michael R. Imdad, Aamer Methods Protoc Study Protocol In pregnancies complicated by sickle cell disease (SCD), the maternal-fetal dyad is at high risk for mortality and morbidity. In healthy pregnancies, maternal nutritional status is a critical factor for the healthy growth and development of the fetus. However, there are no reviews of the current research on the nutritional status of pregnant women with SCD and pregnancy outcomes. First, we aim to assess the burden of malnutrition in pregnant women with SCD. Next, we aim to systematically evaluate if pregnant women with SCD who have poor nutritional status are at increased risk for adverse birth outcomes compared to pregnant women with sickle cell disease and normal nutritional status. We will systematically search multiple electronic databases. Our exposure is pregnant women with SCD and poor nutritional status. The primary outcomes of interest include low birth weight (categorical) and birth weight z-scores (continuous). We will also evaluate maternal and perinatal outcomes as secondary outcomes. We will evaluate the risk of bias and overall certainty of evidence with Risk of Bias in Non-randomized Studies—of Interventions (ROBINS-I), and the overall evidence will be assessed using Grading of Recommendation Assessment, Development, and Evaluation (GRADE) criteria. We will pool findings with a meta-analysis if sufficient homogeneity exists among studies. Findings will be published in a peer-reviewed journal and disseminated to SCD advocacy groups. PROSPERO registration number: 429412. MDPI 2023-09-17 /pmc/articles/PMC10514847/ /pubmed/37736971 http://dx.doi.org/10.3390/mps6050088 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Study Protocol
Klein, Lauren J.
Ayete-Nyampong, John Benaiah
Williams, Annette M.
Harding, Lori A.
Oppong, Samuel A.
Acra, Sari
DeBaun, Michael R.
Imdad, Aamer
Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol
title Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol
title_full Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol
title_fullStr Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol
title_full_unstemmed Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol
title_short Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol
title_sort epidemiology of maternal nutritional status and risk of adverse birth outcomes in undernourished mothers with sickle cell disease: a systematic review and meta-analysis protocol
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514847/
https://www.ncbi.nlm.nih.gov/pubmed/37736971
http://dx.doi.org/10.3390/mps6050088
work_keys_str_mv AT kleinlaurenj epidemiologyofmaternalnutritionalstatusandriskofadversebirthoutcomesinundernourishedmotherswithsicklecelldiseaseasystematicreviewandmetaanalysisprotocol
AT ayetenyampongjohnbenaiah epidemiologyofmaternalnutritionalstatusandriskofadversebirthoutcomesinundernourishedmotherswithsicklecelldiseaseasystematicreviewandmetaanalysisprotocol
AT williamsannettem epidemiologyofmaternalnutritionalstatusandriskofadversebirthoutcomesinundernourishedmotherswithsicklecelldiseaseasystematicreviewandmetaanalysisprotocol
AT hardingloria epidemiologyofmaternalnutritionalstatusandriskofadversebirthoutcomesinundernourishedmotherswithsicklecelldiseaseasystematicreviewandmetaanalysisprotocol
AT oppongsamuela epidemiologyofmaternalnutritionalstatusandriskofadversebirthoutcomesinundernourishedmotherswithsicklecelldiseaseasystematicreviewandmetaanalysisprotocol
AT acrasari epidemiologyofmaternalnutritionalstatusandriskofadversebirthoutcomesinundernourishedmotherswithsicklecelldiseaseasystematicreviewandmetaanalysisprotocol
AT debaunmichaelr epidemiologyofmaternalnutritionalstatusandriskofadversebirthoutcomesinundernourishedmotherswithsicklecelldiseaseasystematicreviewandmetaanalysisprotocol
AT imdadaamer epidemiologyofmaternalnutritionalstatusandriskofadversebirthoutcomesinundernourishedmotherswithsicklecelldiseaseasystematicreviewandmetaanalysisprotocol