Genic constraint against nonsynonymous variation across the mouse genome

BACKGROUND: Selective constraint, the depletion of variation due to negative selection, provides insights into the functional impact of variants and disease mechanisms. However, its characterization in mice, the most commonly used mammalian model, remains limited. This study aims to quantify mouse g...

Descripción completa

Detalles Bibliográficos
Autores principales: Powell, George, Simon, Michelle M., Pulit, Sara, Mallon, Ann-Marie, Lindgren, Cecilia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514939/
https://www.ncbi.nlm.nih.gov/pubmed/37736706
http://dx.doi.org/10.1186/s12864-023-09637-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514939/
https://www.ncbi.nlm.nih.gov/pubmed/37736706
http://dx.doi.org/10.1186/s12864-023-09637-2

Ejemplares similares