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Diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease
Peripheral artery disease (PAD) is a major health problem with increased cardiovascular mortality, morbidity and disabling critical limb threatening ischemia (CLTI) and amputation. Diabetes mellitus (DM) and cigarette smoke are the main risk factors for the development of PAD. Although diabetes rela...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514957/ https://www.ncbi.nlm.nih.gov/pubmed/37735399 http://dx.doi.org/10.1186/s12933-023-01990-6 |
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author | Alnima, T. Meijer, R. I. Spronk, H. M.H. Warlé, M. Cate, H. ten |
author_facet | Alnima, T. Meijer, R. I. Spronk, H. M.H. Warlé, M. Cate, H. ten |
author_sort | Alnima, T. |
collection | PubMed |
description | Peripheral artery disease (PAD) is a major health problem with increased cardiovascular mortality, morbidity and disabling critical limb threatening ischemia (CLTI) and amputation. Diabetes mellitus (DM) and cigarette smoke are the main risk factors for the development of PAD. Although diabetes related PAD shows an accelerated course with worse outcome regarding complications, mortality and amputations compared with non-diabetic patients, current medical treatment does not make this distinction and includes standard antiplatelet and lipid lowering drugs for all patients with PAD. In this review we discuss the pathophysiologic mechanisms of PAD, with focus on differences in thrombo-inflammatory processes between diabetes-related and smoking-related PAD, and hypothesize on possible mechanisms for the progressive course of PAD in DM. Furthermore, we comment on current medical treatment and speculate on alternative medical drug options for patients with PAD and DM. |
format | Online Article Text |
id | pubmed-10514957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105149572023-09-23 Diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease Alnima, T. Meijer, R. I. Spronk, H. M.H. Warlé, M. Cate, H. ten Cardiovasc Diabetol Review Peripheral artery disease (PAD) is a major health problem with increased cardiovascular mortality, morbidity and disabling critical limb threatening ischemia (CLTI) and amputation. Diabetes mellitus (DM) and cigarette smoke are the main risk factors for the development of PAD. Although diabetes related PAD shows an accelerated course with worse outcome regarding complications, mortality and amputations compared with non-diabetic patients, current medical treatment does not make this distinction and includes standard antiplatelet and lipid lowering drugs for all patients with PAD. In this review we discuss the pathophysiologic mechanisms of PAD, with focus on differences in thrombo-inflammatory processes between diabetes-related and smoking-related PAD, and hypothesize on possible mechanisms for the progressive course of PAD in DM. Furthermore, we comment on current medical treatment and speculate on alternative medical drug options for patients with PAD and DM. BioMed Central 2023-09-21 /pmc/articles/PMC10514957/ /pubmed/37735399 http://dx.doi.org/10.1186/s12933-023-01990-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Alnima, T. Meijer, R. I. Spronk, H. M.H. Warlé, M. Cate, H. ten Diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease |
title | Diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease |
title_full | Diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease |
title_fullStr | Diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease |
title_full_unstemmed | Diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease |
title_short | Diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease |
title_sort | diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514957/ https://www.ncbi.nlm.nih.gov/pubmed/37735399 http://dx.doi.org/10.1186/s12933-023-01990-6 |
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