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Postoperative ratio of C-reactive protein to albumin is an independent prognostic factor for gastric cancer

OBJECTIVE: The role of postoperative of the ratio of c-reactive protein to albumin (CRP/Alb ratio) in the prognosis of gastric cancer is rarely evaluated. Our purpose was to investigate the correlation of the postoperative CRP/Alb ratio and long-term prognosis of gastric cancer. METHODS: We enrolled...

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Autores principales: Li, Chenxi, Yang, Xuhui, Li, Hui, Fu, Yan, Wang, Wenying, Jin, Xin, Bian, Lihua, Peng, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515040/
https://www.ncbi.nlm.nih.gov/pubmed/37735699
http://dx.doi.org/10.1186/s40001-023-01334-w
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author Li, Chenxi
Yang, Xuhui
Li, Hui
Fu, Yan
Wang, Wenying
Jin, Xin
Bian, Lihua
Peng, Liang
author_facet Li, Chenxi
Yang, Xuhui
Li, Hui
Fu, Yan
Wang, Wenying
Jin, Xin
Bian, Lihua
Peng, Liang
author_sort Li, Chenxi
collection PubMed
description OBJECTIVE: The role of postoperative of the ratio of c-reactive protein to albumin (CRP/Alb ratio) in the prognosis of gastric cancer is rarely evaluated. Our purpose was to investigate the correlation of the postoperative CRP/Alb ratio and long-term prognosis of gastric cancer. METHODS: We enrolled 430 patients who suffered from radical gastrectomy. The commonly used inflammatory indices, clinical-pathological characteristics and oncologic outcomes were recorded. The median was used to the cut-off value for preoperative and postoperative CRP/Alb ratio, respectively. Kaplan–Meier analysis and Cox proportional hazards regression model were performed to determine its prognostic significance. RESULTS: In univariate analysis, there were significant differences were observed in overall survival (OS) according to perioperative CRP/Alb ratio, c-reactive protein (CRP), serum albumin (Alb), respectively. According to the multivariate analysis, higher postoperative CRP/Alb ratio (HR 2.03, 95% CI 1.55–2.66, P < 0.001), lower postoperative albumin (Alb), higher preoperative c-reactive protein (CRP) and higher postoperative CRP were indicated a shorter overall survival. CONCLUSION: Postoperative inflammatory factors in patients with gastric cancer should be pay attention, especially postoperative CRP/Alb ratio may be an independent predictor of long-term prognosis of gastric cancer.
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spelling pubmed-105150402023-09-23 Postoperative ratio of C-reactive protein to albumin is an independent prognostic factor for gastric cancer Li, Chenxi Yang, Xuhui Li, Hui Fu, Yan Wang, Wenying Jin, Xin Bian, Lihua Peng, Liang Eur J Med Res Research OBJECTIVE: The role of postoperative of the ratio of c-reactive protein to albumin (CRP/Alb ratio) in the prognosis of gastric cancer is rarely evaluated. Our purpose was to investigate the correlation of the postoperative CRP/Alb ratio and long-term prognosis of gastric cancer. METHODS: We enrolled 430 patients who suffered from radical gastrectomy. The commonly used inflammatory indices, clinical-pathological characteristics and oncologic outcomes were recorded. The median was used to the cut-off value for preoperative and postoperative CRP/Alb ratio, respectively. Kaplan–Meier analysis and Cox proportional hazards regression model were performed to determine its prognostic significance. RESULTS: In univariate analysis, there were significant differences were observed in overall survival (OS) according to perioperative CRP/Alb ratio, c-reactive protein (CRP), serum albumin (Alb), respectively. According to the multivariate analysis, higher postoperative CRP/Alb ratio (HR 2.03, 95% CI 1.55–2.66, P < 0.001), lower postoperative albumin (Alb), higher preoperative c-reactive protein (CRP) and higher postoperative CRP were indicated a shorter overall survival. CONCLUSION: Postoperative inflammatory factors in patients with gastric cancer should be pay attention, especially postoperative CRP/Alb ratio may be an independent predictor of long-term prognosis of gastric cancer. BioMed Central 2023-09-21 /pmc/articles/PMC10515040/ /pubmed/37735699 http://dx.doi.org/10.1186/s40001-023-01334-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Li, Chenxi
Yang, Xuhui
Li, Hui
Fu, Yan
Wang, Wenying
Jin, Xin
Bian, Lihua
Peng, Liang
Postoperative ratio of C-reactive protein to albumin is an independent prognostic factor for gastric cancer
title Postoperative ratio of C-reactive protein to albumin is an independent prognostic factor for gastric cancer
title_full Postoperative ratio of C-reactive protein to albumin is an independent prognostic factor for gastric cancer
title_fullStr Postoperative ratio of C-reactive protein to albumin is an independent prognostic factor for gastric cancer
title_full_unstemmed Postoperative ratio of C-reactive protein to albumin is an independent prognostic factor for gastric cancer
title_short Postoperative ratio of C-reactive protein to albumin is an independent prognostic factor for gastric cancer
title_sort postoperative ratio of c-reactive protein to albumin is an independent prognostic factor for gastric cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515040/
https://www.ncbi.nlm.nih.gov/pubmed/37735699
http://dx.doi.org/10.1186/s40001-023-01334-w
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