Selectivity Mechanism of Pyrrolopyridone Analogues Targeting Bromodomain 2 of Bromodomain-Containing Protein 4 from Molecular Dynamics Simulations

[Image: see text] Bromodomain and extra-terminal domain (BET) proteins play an important role in epigenetic regulation and are linked to several diseases; therefore, they are interesting targets. BET has two bromodomains: bromodomain 1 (BD1) and BD2. Selective targeting of BD1 or BD2 may produce dif...

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Detalles Bibliográficos
Autores principales: Shi, Mingsong, Zheng, Xueting, Zhou, Yan, Yin, Yuan, Lu, Zhou, Zou, Zhiyan, Hu, Yan, Liang, Yuanyuan, Chen, Tingting, Yang, Yuhan, Jing, Meng, Lei, Dan, Yang, Pei, Li, Xiaoan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515184/
https://www.ncbi.nlm.nih.gov/pubmed/37744850
http://dx.doi.org/10.1021/acsomega.3c03935

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