Targeting spike glycans to inhibit SARS-CoV2 viral entry

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SARS-CoV-2 spike harbors glycans which function as ligands for lectins. Therefore, it should be possible to exploit lectins to target SARS-CoV-2 and inhibit cellular entry by binding glycans on the spike protein. Burkholderia oklahomensis agglutinin (BOA) is an antiviral lectin that interacts with v...

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Detalles Bibliográficos
Autores principales: Guseman, Alex J., Rennick, Linda J., Nambulli, Sham, Roy, Chandra N., Martinez, David R., Yang, Darian T., Bhinderwala, Fatema, Vergara, Sandra, Schaefer, Alexandra, Baric, Ralph S., Ambrose, Zandrea, Duprex, W. Paul, Gronenborn, Angela M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515186/
https://www.ncbi.nlm.nih.gov/pubmed/37695910
http://dx.doi.org/10.1073/pnas.2301518120
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