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Actin polymerization and depolymerization in developing vertebrates
Development is a complex process that occurs throughout the life cycle. F-actin, a major component of the cytoskeleton, is essential for the morphogenesis of tissues and organs during development. F-actin is formed by the polymerization of G-actin, and the dynamic balance of polymerization and depol...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515290/ https://www.ncbi.nlm.nih.gov/pubmed/37745245 http://dx.doi.org/10.3389/fphys.2023.1213668 |
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author | Bai, Yang Zhao, Feng Wu, Tingting Chen, Fangchun Pang, Xiaoxiao |
author_facet | Bai, Yang Zhao, Feng Wu, Tingting Chen, Fangchun Pang, Xiaoxiao |
author_sort | Bai, Yang |
collection | PubMed |
description | Development is a complex process that occurs throughout the life cycle. F-actin, a major component of the cytoskeleton, is essential for the morphogenesis of tissues and organs during development. F-actin is formed by the polymerization of G-actin, and the dynamic balance of polymerization and depolymerization ensures proper cellular function. Disruption of this balance results in various abnormalities and defects or even embryonic lethality. Here, we reviewed recent findings on the structure of G-actin and F-actin and the polymerization of G-actin to F-actin. We also focused on the functions of actin isoforms and the underlying mechanisms of actin polymerization/depolymerization in cellular and organic morphogenesis during development. This information will extend our understanding of the role of actin polymerization in the physiologic or pathologic processes during development and may open new avenues for developing therapeutics for embryonic developmental abnormalities or tissue regeneration. |
format | Online Article Text |
id | pubmed-10515290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105152902023-09-23 Actin polymerization and depolymerization in developing vertebrates Bai, Yang Zhao, Feng Wu, Tingting Chen, Fangchun Pang, Xiaoxiao Front Physiol Physiology Development is a complex process that occurs throughout the life cycle. F-actin, a major component of the cytoskeleton, is essential for the morphogenesis of tissues and organs during development. F-actin is formed by the polymerization of G-actin, and the dynamic balance of polymerization and depolymerization ensures proper cellular function. Disruption of this balance results in various abnormalities and defects or even embryonic lethality. Here, we reviewed recent findings on the structure of G-actin and F-actin and the polymerization of G-actin to F-actin. We also focused on the functions of actin isoforms and the underlying mechanisms of actin polymerization/depolymerization in cellular and organic morphogenesis during development. This information will extend our understanding of the role of actin polymerization in the physiologic or pathologic processes during development and may open new avenues for developing therapeutics for embryonic developmental abnormalities or tissue regeneration. Frontiers Media S.A. 2023-09-08 /pmc/articles/PMC10515290/ /pubmed/37745245 http://dx.doi.org/10.3389/fphys.2023.1213668 Text en Copyright © 2023 Bai, Zhao, Wu, Chen and Pang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Bai, Yang Zhao, Feng Wu, Tingting Chen, Fangchun Pang, Xiaoxiao Actin polymerization and depolymerization in developing vertebrates |
title | Actin polymerization and depolymerization in developing vertebrates |
title_full | Actin polymerization and depolymerization in developing vertebrates |
title_fullStr | Actin polymerization and depolymerization in developing vertebrates |
title_full_unstemmed | Actin polymerization and depolymerization in developing vertebrates |
title_short | Actin polymerization and depolymerization in developing vertebrates |
title_sort | actin polymerization and depolymerization in developing vertebrates |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515290/ https://www.ncbi.nlm.nih.gov/pubmed/37745245 http://dx.doi.org/10.3389/fphys.2023.1213668 |
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