Cargando…

Actin polymerization and depolymerization in developing vertebrates

Development is a complex process that occurs throughout the life cycle. F-actin, a major component of the cytoskeleton, is essential for the morphogenesis of tissues and organs during development. F-actin is formed by the polymerization of G-actin, and the dynamic balance of polymerization and depol...

Descripción completa

Detalles Bibliográficos
Autores principales: Bai, Yang, Zhao, Feng, Wu, Tingting, Chen, Fangchun, Pang, Xiaoxiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515290/
https://www.ncbi.nlm.nih.gov/pubmed/37745245
http://dx.doi.org/10.3389/fphys.2023.1213668
_version_ 1785108916786429952
author Bai, Yang
Zhao, Feng
Wu, Tingting
Chen, Fangchun
Pang, Xiaoxiao
author_facet Bai, Yang
Zhao, Feng
Wu, Tingting
Chen, Fangchun
Pang, Xiaoxiao
author_sort Bai, Yang
collection PubMed
description Development is a complex process that occurs throughout the life cycle. F-actin, a major component of the cytoskeleton, is essential for the morphogenesis of tissues and organs during development. F-actin is formed by the polymerization of G-actin, and the dynamic balance of polymerization and depolymerization ensures proper cellular function. Disruption of this balance results in various abnormalities and defects or even embryonic lethality. Here, we reviewed recent findings on the structure of G-actin and F-actin and the polymerization of G-actin to F-actin. We also focused on the functions of actin isoforms and the underlying mechanisms of actin polymerization/depolymerization in cellular and organic morphogenesis during development. This information will extend our understanding of the role of actin polymerization in the physiologic or pathologic processes during development and may open new avenues for developing therapeutics for embryonic developmental abnormalities or tissue regeneration.
format Online
Article
Text
id pubmed-10515290
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-105152902023-09-23 Actin polymerization and depolymerization in developing vertebrates Bai, Yang Zhao, Feng Wu, Tingting Chen, Fangchun Pang, Xiaoxiao Front Physiol Physiology Development is a complex process that occurs throughout the life cycle. F-actin, a major component of the cytoskeleton, is essential for the morphogenesis of tissues and organs during development. F-actin is formed by the polymerization of G-actin, and the dynamic balance of polymerization and depolymerization ensures proper cellular function. Disruption of this balance results in various abnormalities and defects or even embryonic lethality. Here, we reviewed recent findings on the structure of G-actin and F-actin and the polymerization of G-actin to F-actin. We also focused on the functions of actin isoforms and the underlying mechanisms of actin polymerization/depolymerization in cellular and organic morphogenesis during development. This information will extend our understanding of the role of actin polymerization in the physiologic or pathologic processes during development and may open new avenues for developing therapeutics for embryonic developmental abnormalities or tissue regeneration. Frontiers Media S.A. 2023-09-08 /pmc/articles/PMC10515290/ /pubmed/37745245 http://dx.doi.org/10.3389/fphys.2023.1213668 Text en Copyright © 2023 Bai, Zhao, Wu, Chen and Pang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Bai, Yang
Zhao, Feng
Wu, Tingting
Chen, Fangchun
Pang, Xiaoxiao
Actin polymerization and depolymerization in developing vertebrates
title Actin polymerization and depolymerization in developing vertebrates
title_full Actin polymerization and depolymerization in developing vertebrates
title_fullStr Actin polymerization and depolymerization in developing vertebrates
title_full_unstemmed Actin polymerization and depolymerization in developing vertebrates
title_short Actin polymerization and depolymerization in developing vertebrates
title_sort actin polymerization and depolymerization in developing vertebrates
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515290/
https://www.ncbi.nlm.nih.gov/pubmed/37745245
http://dx.doi.org/10.3389/fphys.2023.1213668
work_keys_str_mv AT baiyang actinpolymerizationanddepolymerizationindevelopingvertebrates
AT zhaofeng actinpolymerizationanddepolymerizationindevelopingvertebrates
AT wutingting actinpolymerizationanddepolymerizationindevelopingvertebrates
AT chenfangchun actinpolymerizationanddepolymerizationindevelopingvertebrates
AT pangxiaoxiao actinpolymerizationanddepolymerizationindevelopingvertebrates