Peptide Nucleic Acids Containing Cationic/Amino-Alkyl Modified Bases Promote Enhanced Hybridization Kinetics and Thermodynamics with Single-Strand DNA

[Image: see text] Peptide nucleic acids (PNAs) are antisense molecules with excellent polynucleotide hybridization properties; they are resistant to nuclease degradation but often have poor cell permeability leading to moderate cellular activity and limited clinical results. The addition of cationic...

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Detalles Bibliográficos
Autores principales: Podlaski, Frank, Cornwell, Stephen, Wong, Kenny, McKittrick, Brian, Kim, Jae-Hun, Jung, Daram, Jeon, Yeasel, Jung, Kwang-Bok, Tolias, Peter, Windsor, William T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515352/
https://www.ncbi.nlm.nih.gov/pubmed/37744819
http://dx.doi.org/10.1021/acsomega.3c03184

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