FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA

BACKGROUND: Parkinson's disease (PD), characterized by the progressive loss of dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens human health, and is still lack of effective treatment. Dysregulation of N6-methyladenosine (m6A) modification has been implicat...

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Detalles Bibliográficos
Autores principales: Geng, Yan, Long, Xinyi, Zhang, Yuting, Wang, Yupeng, You, Guoxing, Guo, Wenjie, Zhuang, Gaoming, Zhang, Yuanyuan, Cheng, Xiao, Yuan, Zhengqiang, Zan, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515429/
https://www.ncbi.nlm.nih.gov/pubmed/37737187
http://dx.doi.org/10.1186/s12967-023-04461-4

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