Structure–Reactivity Studies of 2-Sulfonylpyrimidines Allow Selective Protein Arylation

[Image: see text] Protein arylation has attracted much attention for developing new classes of bioconjugates with improved properties. Here, we have evaluated 2-sulfonylpyrimidines as covalent warheads for the mild, chemoselective, and metal free cysteine S-arylation. 2-Sulfonylpyrimidines react rap...

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Detalles Bibliográficos
Autores principales: Pichon, Maëva M., Drelinkiewicz, Dawid, Lozano, David, Moraru, Ruxandra, Hayward, Laura J., Jones, Megan, McCoy, Michael A., Allstrum-Graves, Samuel, Balourdas, Dimitrios-Ilias, Joerger, Andreas C., Whitby, Richard J., Goldup, Stephen M., Wells, Neil, Langley, Graham J., Herniman, Julie M., Baud, Matthias G. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515483/
https://www.ncbi.nlm.nih.gov/pubmed/37657082
http://dx.doi.org/10.1021/acs.bioconjchem.3c00322

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