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Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in 2022

On 5 April 2022, the United Kingdom reported an increase of cases of severe acute hepatitis of unknown aetiology in children, several needing hospitalisation and some required liver transplant or died. Thereafter, 35 countries reported probable cases, almost half of them in Europe. Facing the alert,...

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Autores principales: Grau-Pujol, Berta, Vieira Martins, João, Goncalves, Isabel, Rodrigues, Fernanda, de Sousa, Rita, Oliveira, Dina, Bettencourt, Joana, Mendes, Diana, Mateus de Cunha, Inês, Pocinho, Sara, Firme, Ana, dos Santos, Benvinda Estela, Peralta Santos, André, Albuquerque, Maria João, Pinto-Leite, Pedro, Tato Marinho, Rui, Vasconcelos, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515495/
https://www.ncbi.nlm.nih.gov/pubmed/37733237
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.38.2300171
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author Grau-Pujol, Berta
Vieira Martins, João
Goncalves, Isabel
Rodrigues, Fernanda
de Sousa, Rita
Oliveira, Dina
Bettencourt, Joana
Mendes, Diana
Mateus de Cunha, Inês
Pocinho, Sara
Firme, Ana
dos Santos, Benvinda Estela
Peralta Santos, André
Albuquerque, Maria João
Pinto-Leite, Pedro
Tato Marinho, Rui
Vasconcelos, Paula
author_facet Grau-Pujol, Berta
Vieira Martins, João
Goncalves, Isabel
Rodrigues, Fernanda
de Sousa, Rita
Oliveira, Dina
Bettencourt, Joana
Mendes, Diana
Mateus de Cunha, Inês
Pocinho, Sara
Firme, Ana
dos Santos, Benvinda Estela
Peralta Santos, André
Albuquerque, Maria João
Pinto-Leite, Pedro
Tato Marinho, Rui
Vasconcelos, Paula
author_sort Grau-Pujol, Berta
collection PubMed
description On 5 April 2022, the United Kingdom reported an increase of cases of severe acute hepatitis of unknown aetiology in children, several needing hospitalisation and some required liver transplant or died. Thereafter, 35 countries reported probable cases, almost half of them in Europe. Facing the alert, on 28 April, Portugal created a multidisciplinary Task Force (TF) for rapid detection of probable cases and response. The experts of the TF came from various disciplines: clinicians, laboratory experts, epidemiologists, public health experts and national and international communication. Moreover, Portugal adopted the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO) case definition and recommendations. By 31 December 2022, 28 probable cases of severe acute hepatitis of unknown aetiology were reported: 16 male and 17 aged under 2 years. Of these cases, 23 were hospitalised but none required liver transplant or died. Adenovirus was detected from nine of 26 tested cases. No association was observed between adenovirus infection and hospital admission after adjusting for age, sex and region in a binomial regression model. The TF in Portugal may have contributed to increase awareness among clinicians, enabling early detection and prompt management of the outbreak.
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spelling pubmed-105154952023-09-23 Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in 2022 Grau-Pujol, Berta Vieira Martins, João Goncalves, Isabel Rodrigues, Fernanda de Sousa, Rita Oliveira, Dina Bettencourt, Joana Mendes, Diana Mateus de Cunha, Inês Pocinho, Sara Firme, Ana dos Santos, Benvinda Estela Peralta Santos, André Albuquerque, Maria João Pinto-Leite, Pedro Tato Marinho, Rui Vasconcelos, Paula Euro Surveill Perspective On 5 April 2022, the United Kingdom reported an increase of cases of severe acute hepatitis of unknown aetiology in children, several needing hospitalisation and some required liver transplant or died. Thereafter, 35 countries reported probable cases, almost half of them in Europe. Facing the alert, on 28 April, Portugal created a multidisciplinary Task Force (TF) for rapid detection of probable cases and response. The experts of the TF came from various disciplines: clinicians, laboratory experts, epidemiologists, public health experts and national and international communication. Moreover, Portugal adopted the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO) case definition and recommendations. By 31 December 2022, 28 probable cases of severe acute hepatitis of unknown aetiology were reported: 16 male and 17 aged under 2 years. Of these cases, 23 were hospitalised but none required liver transplant or died. Adenovirus was detected from nine of 26 tested cases. No association was observed between adenovirus infection and hospital admission after adjusting for age, sex and region in a binomial regression model. The TF in Portugal may have contributed to increase awareness among clinicians, enabling early detection and prompt management of the outbreak. European Centre for Disease Prevention and Control (ECDC) 2023-09-21 /pmc/articles/PMC10515495/ /pubmed/37733237 http://dx.doi.org/10.2807/1560-7917.ES.2023.28.38.2300171 Text en This article is copyright of the authors or their affiliated institutions, 2023. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Perspective
Grau-Pujol, Berta
Vieira Martins, João
Goncalves, Isabel
Rodrigues, Fernanda
de Sousa, Rita
Oliveira, Dina
Bettencourt, Joana
Mendes, Diana
Mateus de Cunha, Inês
Pocinho, Sara
Firme, Ana
dos Santos, Benvinda Estela
Peralta Santos, André
Albuquerque, Maria João
Pinto-Leite, Pedro
Tato Marinho, Rui
Vasconcelos, Paula
Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in 2022
title Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in 2022
title_full Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in 2022
title_fullStr Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in 2022
title_full_unstemmed Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in 2022
title_short Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in 2022
title_sort task force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in portugal in 2022
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515495/
https://www.ncbi.nlm.nih.gov/pubmed/37733237
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.38.2300171
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